Ph.D. University of Wisconsin. 2005.
My lab's research focuses on complex carbohydrate metabolism by bacteria that live in the human distal gut. In one research path, we investigate metabolism of dietary complex carbohydrates by gut bacteria, which is generally a beneficial process that augments human nutrition. We also study bacterial degradation of host-derived glycans that are present in mucus, which we have recently linked via a molecular genetic approach to the pathology of bacteria-induced colitis. Approaches in the lab include microbial growth and phenotype analysis performed in a high-throughput anaerobic monitoring system, molecular genetics in model bacteria, biochemistry (enzymology, crystallography), comparative genomic analysis in bacteria and use of gnotobiotic animal models.
Science. (2012) 336(6086): 1325-9.
Nat Rev Microbiol. (2012) 10(5):323-35
PLoS Biol. (2011) 9(12):e1001221
J Biol Chem (2011) 286(29):25973-82
Cell Host Microbe. (2008) 4(5):447-57