Dr. Schipani graduated as M.D. first (1985), and Ph.D. later (1989) with Prof. Aldo Pinchera at University of Pisa-Scuola Normale Superiore, Pisa, Italy. In 1988, she specialized in Endocrinology in Pisa. In 1990, she joined the Endocrine Unit led by Prof. Henry Kronenberg at MGH-Harvard Medical School as Postdoctoral Fellow in Prof. Gino Segre's and Prof. Harald Jueppner's laboratories. In 1997, she was appointed Assistant Professor of Medicine. In 2006, she was promoted Associate Professor of Medicine at MGH-Harvard Medical School. In 2011, she was recruited at Indiana University-Medical School as Full Professor of Medicine with tenure and Adjunct Full Professor of Anatomy and Cell Biology. Since 2013, she has been Professor of Orthopaedic Surgery with tenure and Professor of Medicine/Endocrinology at the University of Michigan-Medical School.
Dr. Ernestina Schipani's laboratory has a long-standing interest in the study of bone development. Over the years, her laboratory has used cartilage and bone tissues as models to establish important principles in the broader fields of receptor and hypoxia biology.
Her lab is currently investigating: HIF-1 and mitochondrial respiration in survival and differentiation of chondrocytes; VHL in development of sarcomas of the soft tissue and in synovial fibrosis; HIFs in bone development and homeostasis.
Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM,Schipani E, Risbud MV. Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus. PLoS One. 2014 Oct 22.
Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E.Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014 Sep 1.