Mohammad Fallahi-Sichani obtained a B.Sc. degree in Biotechnology from the University of Tehran and M.Sc. and Ph.D. degrees in Chemical Engineering both from the University of Michigan in 2007, 2009 and 2012, respectively. His PhD work combined multi-scale modeling approaches with wet-lab experiments for the study of mechanisms by which TNF signaling determines immunity to M. tuberculosis infection. He then joined Harvard Medical School as a Life Sciences Research Foundation (LSRF) postdoctoral fellow and was later awarded a K99/R00 Pathway to Independence Award from the NIH/NCI. In 2017, Mohammad joined the faculty of University of Michigan Department of Biomedical Engineering as an Assistant Professor. Since then, his systems biology research has been the recipient of the V Foundation for Cancer Research V Scholar Award (2017) and the DoD CDMRP Career Development Award (2018).
Research in the Fallahi-Sichani Laboratory aims at designing, building and utilizing new experimental and computational tools to analyze, interpret and engineer multi-scale processes that regulate the behavior of human cells and tissues in response to perturbations such as cytokines, stress, cytotoxic and targeted drugs. The lab works at the interface of bioengineering, systems biology and quantitative pharmacology, and relies on new technologies such as multiplex proteomic and genomic measurements, high-throughput microscopy, single-cell analysis, and multi-scale modeling. Our long-term goal is to define, at a single-cell level, molecular mechanisms that underlie adaptive cell fate decisions in the presence of cell-autonomous, microenvironment, and therapy-induced selective pressures, and elucidate how they vary under unhealthy conditions, e.g. in cancer cells. A detailed and network-level understanding of these mechanisms will provide a rational basis for choosing the optimal molecular targets to: (i) maximize therapeutic response, (ii) prevent therapeutic resistance, and (iii) reduce therapy-induced adverse effects.