Dr. Sasaki received his DDS (in 1989) and PhD (in 1998) from the Iwate Medical University, Morioka, Japan. Prior to coming to the University of Michigan School of Dentistry, he worked in the Department of Immunology and Infectious Diseases at the Forsyth Institute in Cambridge, MA.
Dr. Sasaki's research is in the field of apical periodontitis and marginal periodontitis. He aims to integrate various scientific approaches and findings as “dental inflammology" for prevention and cure of dental inflammations.
His findings contributed to an understanding of the functional network of immune cells and cytokines (small proteins inducing cell signaling). He currently focuses on the role of damage-associated molecular patterns. He hypothesizes that serum amyloid A (SAA) links dental inflammations and systemic metabolic disorders bidirectionally. In addition, he assesses the importance of hypoxia-inducible factor 1 (HIF-1) in control of inflammation. He recently established a novel mouse model exhibiting HIF-1-mediated spontaneous resolution of inflammation and periapical wound healing.
Hirai, K., Furusho, H., Kawashima, N., Xu, S., de Beer M.C., Battaglino, R., Van Dyke, T., Stashenko, P., Sasaki, H. (2018). “Serum Amyloid A Contributes to Chronic Apical Periodontitis vis TLR2 and TLR4.” Journal of Dental Research. 2018.
Hirai, K., Furusho, H., Hirota, K., Sasaki, H. (2018). “Activation of hypoxia-inducible factor 1 attenuates periodical inflammation and bone loss.” International journal of oral science. 10(2). pp. 12
Wisitrasameewong, W., Kajiya, M., Movila, A., Rittling, S., Ishii, T., Suzuki, M., Matsuda, S., Mazda, Y., Torruella, M.R., Azuma, M.M., Egashira, K., Freire, M.O., Sasaki, H., Wang, C.Y., Han, X., Taubman, M.A., Kawai, T. (2017). “DC-STAMP is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption.” Journal of Dental Research. 96(6). pp. 685-693.
Kanzaki, H., Movila, A., Kayal, R., Napimoga, M.H., Egashira, K., Dewhirst, F., Sasaki, H., Howait, M., Al-Dharrab, A., Mira, A., Han, X., Taubman, M.A., Nichols, F.C., Kawai, T. (2017). “Phosphoglycerol dihydroceramide, a distinctive ceramics produced by Porphyromonas gingivitis, promotes RANKL-induced osteoclastogenesis by acting on non-muscle myosin II-A (Myh9), an osteoclast cell fusion regulatory factor.” Biochimica et biophysica acta. Molecular and cell biology of lipids. 1862(5). pp. 452-462.
Movila, A., Mawardi, H., Nishimura, K., Kiyama, T., Egashira, K., Kim, J.Y., Villa, A., Sasaki, H., Woo, S.B., Kawai, T. (2016). “Possible pathogenic engagement of soluble Semaphorin 4D produced by γδT cells in medication-related osteonecrosis of the jaw (MRONJ).” Biochemical and biophysical research communications. 480(1). pp. 42-47.