Ph.D: University of Virginia
Postdoc: Yale University
Innate-like T cells include NKT cells, MAIT cells, H2-M3 restricted T cells, CD8aa intraepithelial lymphocytes (IELs), gd T cells, and innate CD4 (iCD4) T cells. Unlike conventional T cells, they exhibit fast and more robust effector function such as cytokine release or cytotoxicity upon activation. They are thought to serve as a bridge between the rapidly occurring innate immunity and the more slowly occurring adaptive immunity. We found that iCD4 T cells suppress other immune cells during an infection by bacteria as well as viruses in animal models. These studies suggest that people who have more iCD4 T cells also may suffer more from infections. However, iCD4 T cells also inhibit immune responses causing allergic reactions in lungs. Therefore, unlike during infection scenarios, iCD4 T cells can help reduce allergies or asthma. Our work in humans showed that iCD4 T cells are abundant during gestation, suggesting that iCD4 T cells may play an important role to protect the fetus during pregnancy. More interestingly, our recent data from tonsils suggest that iCD4 T cells exhibit features of Tfh cells that regulate memory responses. Undoubtedly, iCD4 T cells participate in various immune responses and contribute to development or control of other immune diseases. We will compare human and mouse data and see whether the differences we have found correlate with any immune diseases. Discovering such connections could be the key to identifying preventive measures or cures for diseases that today can only be managed.
Yu Qiao, Lingqiao Zhu, Hanief Sofi, Philip E. Lapinski, Reiko Horai, Kristen Mueller, Gretta L. Stritesky, Xi He, Hung-Sia Teh, David L. Wiest, Dietmar J. Kappes, Philip D. King, Kristin A. Hogquist, Pamela L. Schwartzberg, Derek B. Sant’Angelo, and Cheong-Hee Chang. Development of PLZF expressing innate CD4 T cells require stronger T cell receptor signals than conventional CD4 T cells. PNAS. 2012. 109: 16264–16269
Yu Qiao, B. M. Gray, M. H. Sofi, Laura D. Bauler, and K. A. Eaton, Mary X. D. O’Riordan, and Cheong-Hee Chang. Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacteria infections. Open J. Immunol. 2012. 2:25-39.
M. Hanief Sofi, Yu Qiao, K. Mark Ansel, Masato Kubo, Cheong-Hee Chang. Induction and maintenance of IL-4 expression are regulated differently by the 3’enhancer in CD4 T cells. J. Immunol. 2011. 186: 2792-2799.
M. Hanief Sofi, Zhiping Liu, Lingqiao Zhu, Qiao Yu, Mark H. Kaplan and Cheong-Hee Chang. Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol. Immunol. 2010. 47:1262-1268.
JiHoon Chang, Steven Kunkel and Cheong-Hee Chang. Negative regulation of MyD88-dependent signaling by Interleukin-10 in dendritic cells. PNAS. 2009. 106:18327-32
Wei Li, Hanief Sofi, Svend Rietdijk, Ninghai Wanag, Cox Terhorst and Cheong-Hee Chang. The SLAM-associated protein signaling pathway is required for development of CD4 T cells selected by homotypic thymocyte interaction. 2007. Immunity. 27:763-774.
Wei Li, Hanief Sofi, Norman Yeh, Dipak Patel, Randy Brutkiewicz, Mark Kaplan, and Cheong-Hee Chang. Thymic selection pathway regulates cytokine production potential of CD4 T cells. 2007. J. Exp Med. 204:2145
Wei Li, Moon G. Kim, Tania S. Gourley, Derek Sant'Angelo, and Cheong-Hee Chang. An Alternate Pathway for CD4 T cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T cell Population. 2005. Immunity. 23:375.