Luis Hernandez-Garcia is a research professor in the biomedical engineering department. He received his PhD in biomedical engineering from UNC Chapel Hill, as well as his MS in biomedical engineering and B.S in applied science. In addition to his professorship, Garcia is also the co-director of the BME Department of Engineering Preclinical Imaging Center.
Dr. Hernandez's research interests are focused on developing and integrating techniques for the study of brain function. He has been involved in BOLD (Blood Oxygenation Level Dependent) and ASL (Arterial Spin Labeling) Functional MRI research for a number of years. Primarily, he has been developing ASL methods for quantitatively imaging cerebral perfusion. Perfusion is an indicator of brain function and therefore a very valuable tool, not just for the clinician, but also for the neuroscientist and psychologist. He is currently working on kinetic models for quantifying the ASL signal, and techniques that will improve the SNR and temporal resolution of perfusion measurements. He is very interested in the properties of the BOLD signal and extracting as much information as possible from them. He is also interested in the non-linear temporal characteristics of the vascular response to neuronal activations, and is working on mathematical models of the BOLD response in terms of the underlying physiology. He is also interested in using the statistical properties of the BOLD signal to extract information about the hierarchical relationships between active brain regions. Dr. Hernandez is also working on methods for modeling and measuring the electromagnetic fields produced by transcranial magnetic stimulation (TMS) devices within the brain. Using these techniques, he is trying to improve the targeting and penetration capability of TMS devices. Finally, he has collaborated tightly with research groups in psychology and neurology in the study of attention, memory, pain and depression.
Alsop, D. C., Detre, J. A., Golay, X. , Günther, M. , Hendrikse, J. , Hernandez‐Garcia, L. , Lu, H. , MacIntosh, B. J., Parkes, L. M., Smits, M. , Osch, M. J., Wang, D. J., Wong, E. C. and Zaharchuk, G. (2015), Recommended implementation of arterial spin‐labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn. Reson. Med., 73: 102-116
Buschkuehl, M., Hernandez-Garcia, L., Jaeggi, S.M. et al. Cogn Affect Behav Neurosci (2014) 14: 147. https://doi.org/10.3758/s13415-013-0244-9
L. Gomez, F. Cajko, L. Hernandez-Garcia, A. Grbic and E. Michielssen, "Numerical Analysis and Design of Single-Source Multicoil TMS for Deep and Focused Brain Stimulation," in IEEE Transactions on Biomedical Engineering, vol. 60, no. 10, pp. 2771-2782, Oct. 2013.
Demiralp, E., Demiralp, M. & Hernandez-Garcia, L. J Math Chem (2012) 50: 870. https://doi.org/10.1007/s10910-011-9930-4
Demiralp, M., Demiralp, E. & Hernandez-Garcia, L. J Math Chem (2012) 50: 850. https://doi.org/10.1007/s10910-011-9929-x
Hernandez-Garcia L, Ulfarsson MO: Neuronal Event Detection in FMRI Time Series Using Iterative Deconvolution Techniques. Magnetic Resonance Imaging, 2011 Apr;29(3):353-64.. PMID: 21232893
Demeter E, Hernandez-Garcia L, Sarter M: Top-down control of attention: a continuous arterial spin labeling (ASL) study of the effects of distraction on sustained attention. Neuroimage, 2011 Jan 15;54(2):1518-29. PMID: 20851189
Hernandez-Garcia L, Jahanian H, Greenwald M, Zubieta JK, Peltier SJ: Real-Time Functional MRI Using Pseudo-Continuous Arterial Spin Labeling, Magnetic Resonance in Medicine, 2011 Mar 28; 24(10), p1202-1209; doi: 10.1002/mrm.22922. PMID 21446035.
Demiralp E, Demiralp M, Hernandez-Garcia L: A Probabilistic Foundation for Dynamical Systems: Phenomenological Reasoning and Principal Characteristics of Probabilistic Evolution. J. Mathematical Chemistry, 2011, 1-11, doi:10.1007/s10910-011-9930-4.
Demiralp E, Demiralp M, Hernandez-Garcia L A Probabilistic Foundation for Dynamical Systems: Theoretical Background and Mathematical Formulation. J. Mathematical Chemistry 2012, vol. 50, no4, pp. 850-869
Nielsen JF, Hernandez-Garcia L: Functional perfusion imaging using pseudo-continuous Arterial Spin Labeling with low-flip-angle segmented 3D spiral readouts. Magnetic Resonance in Medicine, in press. DOI: 10.1002/mrm.24261
Demiralp E, Jaeggi S, Buschkuehl M, Matta J, Thompson RJ, Hernandez-Garcia L, Feldman Barrett L, Ellsworth PC, Gotlib IH: Jonides J: Feeling Blue or Turquoise? Emotional Differentiation in Major Depressive Disorder. Psychological Science, in press.
Hernandez-Garcia L, Buschkuehl M: Advances in Longitudinal fMRI diagnostic tests, Expert Opinion on Medical Diagnostics, (DOI:10.1517/17530059.2012.686995).