Diploma, Pharmacy, China Pharmaceutical University College of Pharmacy
MS, Pharmacology, China Pharmaceutical University College of Pharmacy
MBA, Nanjing University School of Business, China
Ph.D. Pharmaoclogy, China Pharmaceutical University College of Pharmacy
Postdoctoral Fellow, Medical University of South Carolina College of Pharmacy
1. Using a combined approach of pharmacogenomics, proteomics, and metabonomics to identify biomarkers associated with inter-individual variability in pharmacotherapy and apply these biomarkers to the practice of personalized medicine;
2. Using both in vitro and in vivo models to study the function and regulation of drug transporters expressed in the blood-brain barrier and its impact on drug disposition in the central nervous system;
3. Elucidating the role of uptake-2 transporters in the maintenance of neurotransmitter homeostasis, and evaluating these transporters as a potential drug target for neuropsychiatric disorders
Wang X, Wang G*, Shi J, Aa J, Comas R, Liang Y, Zhu HJ* Evaluation of carboxylesterase 1 as a determinant of the activation of ACE inhibitor prodrugs. Pharmacogenomics J. 2015 Jun 16. doi: 10.1038/tpj.2015.42.
Wang X, Zhu HJ, Munoz J, Gurley BJ, Markowitz JS. An ex vivo approach to botanical-drug interactions: A proof of concept study. J Ethnopharmacol. 2015 Jan 24. doi: 10.1016/j.jep.2015.01.021.
Wang X, Zhu HJ*, Markowitz JS. Carboxylesterase 1-Mediated Drug–Drug Interactions between Clopidogrel and Simvastatin. Biol. Pharm. Bull. 38, 292–297 (2015)
Kristensen KE, Zhu HJ, Wang X, Gislason GH, Torp-Pedersen C, Rasmussen HB, Markowitz JS, and Hansen PR. Clopidogrel bioactivation and risk of bleeding in patients co-treated with ACE inhibitors after myocardial infarction: A proof of concept study. Clin Pharmacol Ther. 2014 Sep 15. doi: 10.1038/clpt.2014.183. [Epub ahead of print]
Langaee T*, Zhu HJ*, Wang X, Rouby NE, Markowitz JS, Goldstein JA, and Johnson JA. The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping. Pharmacogenetics and Genomics 2014 Aug; 24(8):381-6., *co-first authors
Kawaguchi-Suzuki M, Frye RF, Zhu HJ, Brinda BJ, Chavin KD, Bernstein HJ, and Markowitz JS. The effects of Milk Thistle (Silybum marianum) on human cytochrome P450 activity. Drug Metabolism and Disposition, 2014 Jul 15. pii: dmd.114.057232.
Markowitz JS, Zhu HJ, Patrick KS. Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability. Journal of Child and Adolescent Psychopharmacology. 2013, 23 (10), 648-654
Zhu HJ, Brinda BJ, Chavin KD, Bernstein HJ, Patrick KS, Markowitz JS. An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: A dose escalation study. Drug Metab Dispos. 2013 41 (9), 1679-1685
Zhu HJ, Wang X, Gawronski B, Brinda B, Angiolillo DJ, Markowitz JS. Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation. J Pharmacol Exp Ther. 2013 Mar;344(3):665-72.
Zhu HJ*, Markowitz JS*. Carboxylesterase 1 (CES1) genetic polymorphisms and oseltamivir activation. Eur J Clin Pharmacol. 2012: DOI 10.1007/s00228-012-1350-2 * corresponding author
Markowitz JS and Zhu HJ. Limitations of in vitro Assessments of the Drug Interaction Potential of Botanical Supplements. Planta Medica. 2012 Sep;78(13):1421-7.
Brinda B, Zhu HJ, Markowitz JS. A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 1;902:1-9.
Zhu HJ*, Appel DI, Gründemann D, Richelson E, Markowitz JS*. Evaluation of organic cation transporter 3 (SLC22A3) inhibition as a potential mechanism of antidepressant action. Pharmacol Res. 2012 Apr;65(4):491-6. * corresponding author
Appel DI, Brinda B, Markowitz JS, Newcorn JH, Zhu HJ*. A liquid chromatography/tandem mass spectrometry assay for the analysis of atomoxetine in human plasma and in vitro cellular samples. Biomed Chromatogr 2012 Jan 25. doi: 10.1002/bmc.2706 * corresponding author