My research focuses on the inflammatory response in sepsis. Currently, we are funded to examine the therapeutic use of fibrocytes in sepsis. Adoptive transfer of these cells improves sepsis survival in the CLP model and increases splenic T cell numbers. Our research is designed to find the mechanisms for the enhanced survival and the molecular mechanism behind the increase T cell numbers. In addition, we are involved in development of animal models of hemorrhage and abdominal trauma. Finally, we are devoted to the application of scientific methodology to balance animal welfare needs while preserving the integrity of biomedical research. To this end, we explore the need for humane endpoints and the use of analgesics in models of inflammation.
Cotroneo T, Nemzek J, Bayliss J, Su G. Lipopolysaccharide binding protein (LBP) inhibitory peptide alters hepatic inflammatory response post hemorrhagic shock. Innate Immun. Epub ahead of print April 25, 2012
Cotroneo T, Hugunin K, Shuster K, Hwang H, Kakaraparthi B, Nemzek-Hamlin J. Effects of buprenorphine on cecal ligation and puncture models in C57BL/6 mice. J Am Assoc Lab Anim Sci, 51(3): 357-65, 2012.
Nemzek JA, Abatan O, Fry, C, Mattar A. Functional contribution of CXCR2 to lung injury after aspiration of acid and gastric particulates. Am J Physiol Lung Cell Mol Physiol 298: L382-L391, 2010.
Hugunin K, Fry C, Shuster K, Nemzek JA. Effects of tramadol and buprenorphine on select immunologic factors in a cecal ligation and puncture model. Shock.34:250-260, 2010
Cho K, Chiu S, Lee Y, Greenhalgh D, Nemzek JA. Experimental polymicrobial peritonitis-associated transcriptional regulation of murine endogenous retroviruses (MuERVs) in the liver and lung. Shock 32:147-158, 2009.