University of Michigan – General Psychiatry Residency
University of Michigan – M.D., Ph.D. (Neuroscience)
University of Southern California – B.S. (Biological Sciences)
Addiction, Post-Traumatic Stress Disorder, Dual Diagnosis
My research uses an animal model to investigate why some individuals may be inherently prone to developing co-morbid psychiatric disorders, more specifically addiction and post-traumatic stress disorder (PTSD). One psychological vulnerability factor that seems to be shared between addiction and PTSD is a tendency to attribute excessive emotional and motivational significance to neutral cues that are paired with emotionally salient events. Using Pavlovian behavioral methods, we can identify rats that are more susceptible to developing addiction- and PTSD-like behaviors before they have ever been exposed to drugs or traumatic experiences. This allows us to use molecular, pharmacological, and other techniques to help identify the neurobiological basis of shared vulnerability to both PTSD and addiction.
Morrow JD, Maren S, and Robinson TE. (2011) Individual variation in the propensity to attribute incentive salience to an appetitive cue predicts the propensity to attribute motivational salience to an aversive cue. Behav Brain Res; 220(1):238-243.
Meyer, PJ, Lovic V, Saunders BT, Yager LM, Flagel SB, Morrow JD, and Robinson TE. (2012) Quantifying individual variation in the propensity to attribute incentive salience to reward cues. PLoS One; 7(6): e38987. doi:10.1371/journal.pone.0038987.
Morrow JD, Saunders BT, Maren S, and Robinson TE. (2015) Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats. Behav Brain Res; 276:59-66
Fitzpatrick CJ, Perrine SA, Ghoddousi F, Galloway MP, and Morrow JD. (2016) Sign-trackers have elevated myo-inositol in the nucleus accumbens and ventral hippocampus following Pavlovian conditioned approach. J Neurochem; doi: 10.1111/jnc.13524. [Epub ahead of print]