Ph.D. Massachusetts Institute of Technology. 2007.
M.S. University of California, Los Angeles. 2002.
B.E. University of Science and Technology of China. 2000.
Our group's interests lie at the nexus of micro/nanoengineering, biophysics, biology, and biotechnology. Currently, we focus on developing integrated systems for high throughput quantitative micro/nanoscale analysis of molecular and cellular functions. Specifically, we are developing integrated techniques to investigate biological entities (from nanoscale biomolecules to micron-sized mammalian cells) confined in micro/nanofluidic environments. We study molecular and cellular interactions with these micro/nanofluidic structures and explore the opportunity of using these micro/nanofluidic devices for ultra-sensitive biosensing and detection as well as for efficient biosample preparation. We are also interested in developing synthetic micro/nanoscale cellular microenvironment to direct cellular behaviors, and further employing them to identify the extrinsic physical factors and their downstream signaling pathways that regulate cell functions.
Jianping Fu, Reto B. Schoch, Anna L. Stevens, Steven R. Tannenbaum, and Jongyoon Han. A patterned anisotropic nanofluidic sieving structure for continuous-flow separation of DNA and proteins. Nature Nanotechnology, vol. 2, pp.121-128, 2007.Â PMCID: PMC2621439.
Jianping Fu, Yang-Kao Wang, Michael T. Yang, Ravi A. Desai, Xiang Yu, Zhijun Liu, and Christopher S. Chen. Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nature Methods, vol. 7, pp.733-736, 2010. PMCID: PMC3069358.
Shinuo Weng, and Jianping Fu. Synergistic regulation of cell function by matrix rigidity and adhesive pattern. Biomaterials, vol. 32, pp. 9584-9593, 2011. (PMC Journal - In process)
Jennifer M. Mann, Raymond Hiu-Wai Lam, Shinuo Weng, Yubing Sun, and Jianping Fu.Â A silicone-based stretchable micropost array membrane for monitoring live-cell subcellular cytoskeletal response. Lab on Chip, vol. 12, pp. 731-740, 2012. (PMC Journal - In process)
Weiqiang Chen, Luis G. Villa-Diaz, Yubing Sun, Shinuo Weng, Raymond Hiu-Wai Lam, Paul H. Krebsbach, and Jianping Fu. Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells. ACS Nano, vol. 6, pp. 4094-4103, 2012. PMCID: PMC3358529.
Yubing Sun, Luis G. Villa-Diaz, Raymond Hiu-Wai Lam, Weiqiang Chen, Paul H. Krebsbach, and Jianping Fu. Matrix mechanics regulates fate decisions of human embryonic stem cells. PLoS ONE, vol. 7, e37178, 2012. PMCID: PMC3353896.
Raymond Hiu-Wai Lam, Shinuo Weng, Wei Lu, and Jianping Fu. Live-cell subcellular measurement of cell stiffness using a microengineered stretchable micropost array membrane. Integrative Biology, vol. 4, pp. 1289-1298, 2012. PMCID: PMC4088946.
Yubing Sun, and Jianping Fu. Mechanobiology: A new frontier for human pluripotent stem cells. Integrative Biology, vol. 5, pp. 450-457, 2013. (PMC Journal - In process)