Dr. Karen McLean received her MD and PhD in cancer biology from the University of Michigan. She continued her clinical training at the institution culminating with fellowship training in Gynecologic Oncology. She performs translational research on ovarian cancer, with the goal of improved treatment options for women with this disease.
Dr. McLean's research interests include pathogenesis of gynecologic cancers, with special emphasis on ovarian cancer; the role of stem cells in ovarian cancer development and recurrence; the preclinical and clinical investigation of new treatments for ovarian cancer.
McLean K, Gong Y, Choi Y, Deng N, Yang K, Bai S, Cabrera L, Keller E, McCauley L, Cho KR, Buckanovich RJ: Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production. J Clin Invest 121(8): 3206-19, 2011. PM21737876/PMC3148732
Stasenko M, Plegue M, Sciallis AP, McLean K: Clinical response to antiestrogen therapy in platinum-resistant ovarian cancer patients and the role of tumor estrogen receptor expression status. International journal of gynecological cancer: official journal of the International Gynecological Cancer Society 25(2): 222-8, 2015. PM25500503
Burgos-Ojeda D, McLean K, Bai S, Pulaski H, Gong Y, Silva I, Skorecki K, Tzukerman M, Buckanovich RJ: A novel model for evaluating therapies targeting human tumor vasculature and human cancer stem-like cells. Cancer Res 73(12): 3555-65, 2013. PM23576551/PMC3686886