Kelly B. Arnold received her Ph.D. in Biomedical Engineering from the University of Virginia, and was a Postdoctoral Fellow of Biological Engineering from MIT.
The Arnold Lab uses various computational and experimental approaches to generate new systems-level insight into the immune system, for potential use in development of new therapeutics and diagnostics. Of special interest are mucosal surfaces in the female reproductive tract and the lung where the immune system is the first line of defense against infection but also contributes to problematic inflammatory processes. Specific projects in the lab currently involve: 1) working with South African researchers to understand complex immune processes involved in infectious disease susceptibility in the female reproductive tract and 2) collaboration with University of Michigan clinicians to better understand the role of the immune system in organ transplant success.
A.W. Chung*, M.P. Kumar*, K.B. Arnold*, W.H. Yu*, M.K. Schoen, L.J. Dunphy, T.J. Suscovich, N. Frahm, C. Linde, A.E. Mahan, M. Hoffner, H. Streeck, M.E. Ackerman, J. McElrath, H. Schuitemaker, M.G. Pau, L.R. Baden, J.H. Kim, N.L. Michael, D.H. Barouch, D.A. Lauffenburger, and G. Alter. “Dissecting the polyclonal nature of vaccine-induced humoral immunity using Systems Serology.” Cell (2015). Accepted.
K. B. Arnold*, G.S. Szeto*, G. Alter, D.J. Irvine, and D.A. Lauffenburger. “CD4+ T celldependent and -independent cytokine/chemokine network changes in immune responses of HIV-infected individuals.” Science Signaling (2015). Accepted.
K. B. Arnold*, A. Burgener*, K. Birse, L. Romas, L.J. Dunphy, K. Shahabi, M. Abou, J. Kwatampora, B. Nyanga, J. Kimani, L. Liebenberg, L. Masson, S.S. Abdool Karim, J.S. Passmore, D.A. Lauffenburger, R. Kaul, and L.R. McKinnon. “Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered Kelly B. Arnold 2 expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.” Mucosal Immunology (2015) Jun 24 [Epub ahead of print].
K. Birse, K.B. Arnold, R.M. Novak, S. McCorrister, G.R. Westmacott, T.B. Ball, D.A. Lauffenburger, and A. Burgener. “Molecular signatures of immune activation and epithelial barrier remodeling are enhanced during the luteal phase of the menstrual cycle: implications for HIV susceptibility.” Journal of Virology (2015) Sep 1;89(17):8793-805.
R.P. Madan, J. Tugetman, L. Masson, L. Werner, A. Grobler, K. Mlisana, Y. Lo, D. Che, K.B. Arnold, S.S. Abdool Karim, J.S. Passmore, and B.C. Herold. “Innate antibacterial activity in female genital tract secretions is associated with increased risk of HIV acquisition.” AIDS Research and Human Retroviruses (2015) Jul 14.