Ph.D. - Bioengineering; M.S. - Bioengineering; M.S. - Mechanical engineering; B.S. - Mechanical engineering
I earned a BS and MS in Mechanical Engineering at Wayne State University in Detroit, and an MS and PhD in Bioengineering from U of M. I conducted a post-doctoral fellowship at Case Western Reserve University in Cleveland, Ohio, where I then served as Assistant Professor in the Department of Orthopaedics. In 1999, I accepted a position in the Department of Orthopaedics at the Mount Sinai School of Medicine in New York City. I returned to the Department of Orthopaedic Surgery at The University of Michigan in September, 2011.
My research program focuses on understanding how complex physiological systems such as the skeletal system establish function during growth and maintain function during aging. Having a better understanding of how complex systems work is expected to benefit efforts to reduce fracture risk by identifying the genetic and environmental factors that impair (or promote) specific components of the functional adaptation process that compromise (or improve) musculoskeletal health. A pattern in the way individuals coordinate their traits was identified in a mouse model and then successfully translated to the human skeleton. This pattern or network of trait interactions has experimental value in that genetic factors regulating each component of the network can be teased out and studied. The network also has tremendous clinical value because it means a person's fracture risk can be predicted and will provide insight into novel prophylactic therapies. Evaluating acquired trait sets is expected to provide a more flexible, personalized approach to identifying novel biomechanical and biological pathways contributing to bone fragility.
Jepsen KJ, Centi A, Duarte GF, Galloway K, Goldman H, Hampson N, Lappe JM, Cullen DM, Greeves J, Izard R, Nindl BC, Kraemer WJ, Negus CH, Evans RK. Biological constraints that limit compensation of a common skeletal trait variant lead to inequivalence of tibial function among healthy young adults. Journal of Bone and Mineral Research, 26:2872-2885, 2011. Jepsen KJ, Courtland H-W, Nadeau JH. Genetically-determined phenotype covariation networks control bone strength. J Bone Miner Res, 25:1581-1593, 2010. Jepsen KJ. Systems analysis of bone. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 1(1):73-88, 2009. Epelboym Y, Gendron RN, Mayer J, Fusco J, Nasser P, Gross G, Ghillani R, Jepsen KJ. The inter-individual variation in femoral neck width is associated with the acquisition of predictable sets of morphological and tissue-quality traits and differential bone loss patterns. Journal of Bone and Mineral Research, 27(7):1501-1510, 2012. Bhola S, Chen J, Fusco J, Duarte GF, Andarawis-Puri N, Ghillani R, Jepsen KJ, Variation in childhood skeletal robustness is an important determinant of cortical area in young adults. Bone, 49:799-809, 2011.