Ph.D. Massachusetts Institute of Technology. Physical Chemistry. 2003
M.Eng. Kyoto University, Japan. Biological Chemistry.
B.Eng. Kyoto University, Japan. Polymer Chemistry.
Dr. Kuroda's primary interest is to design and synthesize amphiphilic polymers/oligomers that can actively interact with cell membranes and use these compounds to understand polymer-lipid interactions by investigating the physical properties and biological activities of polymers in lipid layers.
Dr. Kuroda's laboratory will study the membrane-disrupting action of antimicrobial polymers and the translocation of polymers as potential drug carriers. He will also focus on the creation of fluorescent oligomer probes to examine the morphology of lipids membrane, which may also be useful in monitoring cellular activity and conditions. These projects will provide insight into polymer-lipid interactions, aiding in the development of polymers as alternatives for antibiotics or drug/gene vectors and as imaging agents for the cell membranes. This research is highly interdisciplinary, involving the fields of synthetic polymer chemistry, biochemistry, and physical chemistry, and is oriented to the practical aspects of biomedical and pharmaceutical applications
Haruko Takahashi, Kenji Yumoto, Kazuma Yasuhara, Enrico T. Nadres, Yutaka Kikuchi, Russell S. Taichman & Kenichi Kuroda (Haruko Takahashi and Kenji Yumoto contributed equally.) "Anticancer polymers designed for killing dormant prostate cancer cells" Scientific Reports, 2018 in press.
Hamid Mortazavian, Leanna L. Foster, Rajani Bhat, Shyrie Patel, and Kenichi Kuroda. “Decoupling the Functional Roles of Cationic and Hydrophobic Groups in the Antimicrobial and Hemolytic Activities of Methacrylate Random Copolymers” Biomacromolecules, 2018
Premysl Mikula Marie Mlnarikova Haruko Takahashi Pavel Babica Kenichi Kuroda Ludek Blaha Iva Sovadinova. "Branched Poly(ethylene imine)s as Anti‐algal and Anti‐cyanobacterial Agents with Selective Flocculation Behavior to Cyanobacteria over Algae" Macromolecular Bioscience, 2018
Haruko Takahashi, Gregory A Caputo, Satyavani Vemparala, and Kenichi Kuroda. "Synthetic random copolymers as a molecular platform to mimic host-defense antimicrobial peptides" (Review) Bioconjugate Chemistry