2008 Ph.D., Neuroscience, Yale University
2002 B.Sc., Biochemistry, University of Waterloo
Research in the Kwan laboratory is aimed at understanding the developmental processes that underlie cortical circuit assembly, their evolution during the emergence of human cognition, and their dysregulation in neurodevelopmental disorders.
Shim S, Kwan KY, Li M, Lefebvre V, Sestan N. Cis-regulatory control of corticospinal system development and evolution (2012). Nature, 486: 74-79.
Kwan KY, Lam MMS, Johnson MB, Dube U, Shim S, et al. (2012). Species-dependent post-transcriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell, 149: 899-911.
Kwan KY, Sestan N, Anton ES (2012). Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex. Development, 139:1535-1546.
Barak T, *Kwan KY, Louvi A, Demirbilek V, Saygı S, et al. (2011). Recessive LAMC3 mutations cause malformations of occipital cortical development. Nature Genetics, 43: 590-594. [*equal contributors]
Kwan KY, *Lam MMS, Krsnik Z, Imamura Kawasawa Y, Lefebvre V, Sestan N (2008). SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. Proc Natl Acad Sci U S A, 105: 16021-16026. [*equal contributors]
Abelson JF, *Kwan KY, *O'Roak BJ, Baek DY, Stillman AA, et al. (2005). Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science, 310: 317-320. [*equal contributors]