Dr. Samuels received her Ph.D. from the University of Chicago (1984) and B.S. from Michigan State University.
Dr. Samuelson’s research program examines the development and function of epithelial cells in stomach and intestine. We are interested in how basic developmental pathways, growth factors and immune modulators function to regulate epithelial cell proliferation and differentiation in normal physiology and disease. Our approach is to use genetically engineered mouse models and organ culture systems to interrogate pathways regulating epithelial cell homeostasis. Recent studies have focused on the importance of Notch signaling for regulating stem and progenitor cells. In the intestine, Notch plays a fundamental role in cell lineage choice between absorptive enterocytes and secretory cell types (goblet, endocrine, Paneth). More recent findings demonstrate a distinct function for Notch signaling to maintain the intestinal stem cell. Notch also regulates cellular proliferation and cell fate determination in the stomach, suggesting that this signaling pathway plays a fundamental role in regulating epithelial cell renewal in the gastrointestinal tract.
VanDussen, K.L., A. J. Carulli, T.M. Keeley, S.R. Patel, B.J. Puthoff, S.T. Magness, I.T. Tran, I. Mallard, C. Siebel, A. Kolterud, A. Grosse, D.L. Gumucio, S.A. Ernst, Y-H Tsai, P. Dempsey and L.C. Samuelson. Notch Signaling Modulates Proliferation and Differentiation of Intestinal Crypt Base Columnar Stem Cells. Development 139:488-497 (2012).
Liu, Z., E.S. Demitrack, T.M. Keeley, K.A. Eaton, M. El-Zaatari, J.L. Merchant and L.C. Samuelson. IFNg Contributes to the Development of Gastric Epithelial Cell Metaplasia in Huntingtin Interacting Protein 1 Related (Hip1r)-Deficient Mice. Lab Invest 92:1045-1057 (2012).
Keeley, T.M. and L.C. Samuelson. Cytodifferentiation of the postnatal mouse stomach in normal and Huntingtin Interacting Protein 1 related (Hip1r)-deficient mice. Amer. J. Physiol-Gastrointest. Liver Physiol. 299:G1241-51(2010).
VanDussen, K.L. and L.C. Samuelson. Mouse Atonal Homology 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev. Biol. 346:215-23 (2010).