Dr. Lee obtained his Ph.D. in 2006 from Korea Advanced Institute of Science and Technology and received his postdoctoral training at the Department of Pharmacology at the University of California, San Diego. Currently, Dr. Lee is an assistant professor at the Department of Molecular and Integrative Physiology at the University of Michigan.
Professor Lee's lab focuses on diverse physiologies including growth, development and aging that are controlled by signal transduction networks. Recently, their research has revealed that Sestrin, a stress-inducible protein, is a feedback inhibitor of TOR signaling, and that loss of Sestrin can cause various chronic TOR-associated pathologies, such as fat accumulation, mitochondrial dysfunction, cardiac arrhythmia and muscle degeneration. These phenotypes are quite similar to those associated with obesity, aging and lack of exercise, which are currently some of the major public health issues facing our society. They expect that further research on mammalian Sestrin-family proteins may provide a novel way to attenuate aging and prevent or treat age-associated diseases in humans.
Lee, J. H., Koh, H., Kim, M., Kim, Y., Lee, S. Y., Karess, R., Lee, S., Shong, M., Kim, J., Kim, J. and Chung, J. (2007) Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature, 447, 1017-1020. PMID: 17486097
Park, E. J., Lee, J. H., Yu, G., He, G., Ali, S. R., Holzer, R. G., Osterreicher, C. H., Takahashi, H., Karin, M. (2010) Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell, 140, 197-208. PMID: 20141834, PMCID: PMC2836922
Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science, 327, 1213-1218. PMID: 20203043, PMCID: PMC2866632
Sun, D., Lee, G., Lee, J. H.*, Kim, H., Rhee, H., Park, S., Kim, K., Kim, Y., Kim, B. Y., Hong, J., Park, C., Choy, H. E., Kim, J. H., Jeon, Y. H., Chung, J. (2010) A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nat. Struct. Mol. Biol. 17, 1188-1194. PMID: 20818390 *a co-first author
Lee, J. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrins at the crossroad between stress and aging. Aging, 2, 369-374. PMID: 20606249, PMCID: PMC2919257
Lee, J. H.**, Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M. H., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin 2 and 3. Cell Metab., 16, 311-321. PMID: 22958918 **a co-corresponding author.