New Diabetes Research Investigator Award, Seattle
VCU School of Medicine Outstanding Teaching Award-2007
Outstanding Research Award, VCU School of Medicine-2006
Research in my laboratory is concerned with two broad areas: 1) The role of ion channels and membrane excitability in the control of insulin exocytosis from pancreatic islets of Langerhans in health and disease, and 2) the cellular and molecular mechanisms which lead to synaptic dysfunction following traumatic brain injury (TBI). Techniques used in our research include patch clamp electrophysiology, intracellular free [Ca2+] measurements, PCR and RT-PCR, western blotting, FRET, immunocytochemistry, mathematical modeling, cell culture, confocal microscopy, gene transfection (including using adenovirus approaches) and secretion measurements.
Zhang, L., Rzigalinski, B.A., Ellis, E.F. and Satin, L.S. (1996). Reduction of voltage-dependent Mg2+ blockade of NMDA currents in mechanically injured cortical neurons. Science 274:1805-1976.
Tavalin, S.J., Ellis, E.F. and Satin, L.S. (1997). Inhibition of the electrogenic Na pump underlies delayed depolarization of cortical neurons following mechanical injury or glutamate. J. Neurophysiol. 77: 632-638.
Aguayo, L.G., Espinoza, F., Kunos, G. and Satin, L.S. (1998). Effects of intracellular calcium on GABAA receptors in mouse cortical neurons. Pflugers Archiv 435: 382-387.
Satin, L.S. and Kinard, T.A. (1998). Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate and GABA transmit? Endocrine 8: 213-223.
Goforth, P.B., Ellis, E.F. and Satin, L.S. (1999). Enhancement of AMPA-mediated current following mechanical injury in cortical neurons, J. Neuroscience 19: 7367-7374.
Khan, F., Goforth P, Zhang M and Satin, L.S. (2001). Insulin activates ATP-sensitive K channels in pancreatic ß-cells through a phosphatidylinositol sensitive pathway. Diabetes 50:2192-2198.34.
Calabrese A, Serre-Beinier V, Zhang M, Caton D, Mas C, Satin LS, and Meda P. (2003). Connexin 36 controls synchronization of Ca2+ oscillations and insulin secretion of MIN6 cells. Diabetes 52: 417-424.
Goforth, P.B., Ellis, E.F. and Satin, L.S. (2004). Mechanical injury modulates AMPA receptor kinetics via an NMDA receptor dependent pathway. J. Neurotrauma 21: 259-270.
Nunemaker CS, Zhang M, Wasserman DH, McGuinness OP, Powers AC, Bertram R, Sherman A, Satin LS (2005). Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo? Diabetes. 2005 54(12):3517-22.
Zhang M, Houamed K, Kupershmidt S, Satin L.S. (2005). Pharmacological properties and functional role of Kslow current in mouse pancreatic beta cells. J. Gen. Physiol. 126: 353-363.
Nunemaker CS, Wasserman DH, McGuinness OP, Sweet IR, Teague JC, Satin LS (2006). Insulin secretion in the conscious mouse is biphasic and pulsatile.Am J Physiol Endocrinol Metab. 290(3):E523-9.
Nunemaker C and Satin, L.S. (2005). A tale of two rhythms: a comparative review of pulsatile endocrine systems. (Invited review). CellScience Reviews (online journal).