Ph.D., University of Pennsylvania Chemical and Biochemical Engineering 1986 M.S., University of Pennsylvania Chemical and Biochemical Engineering 1983 B.S., University of Notre Dame Chemical Engineering 1981
Microfabricated Reaction/Separation Systems. Many chemical analysis systems require extensive measuring, mixing, and separation/detection operations before data can be collected. Some of these tests, such as hospital tests for bacterial infections, would greatly benefit by an increased processing speed; all would benefit by a decrease in labor and materials costs. In recent years, a number of companies have integrated all the required steps for a particular test into a simple format (home pregnancy kits are a good example). Most of these formats, though, are far from robust and can usually only handle "yes/no" results.
We are constructing miniaturized chemical analysis systems using silicon fabrication techniques. The devices consist of micron-scale reaction, separation, and detection systems connected by a series of micromachined channels. Samples are injected into these devices and then moved between components by a variety of techniques including surface tension control and hydrophobic/hydrophilic patches. Reaction chambers in these devices can be used for selective amplification or digestion of reactants. The products of these reactions can then be analyzed using separation techniques such as simple gel electrophoresis. Integration of all these steps produces a micron-scale device that can act as an intelligent sensor. Currently, our main focus is the analysis and sequencing of DNA although the techniques used can be applied to a variety of chemical analysis systems.
Chang DS, Langelier SM, Zeitoun RI, and MA Burns, “A Venturi Microregulator Array Module for Distributed Pressure Control,” Microfluidics and Nanofluidics, 9 (4-5), 678-680 (2010).
Wang F and Burns MA, “Multiphase Bioreaction Microsystem With Automated On-Chip Droplet Operation,” Lab on a Chip, 10 (10), 1308-1315 (2010).
Wang F and Burns MA, “Droplet-based Microsystem For Multi-Step Bioreactions,” Biomedical Microdevices, 12 (3), 533-541 (2010)
Zeitoun RI, Chang DS, Langelier SM, Mirecki-Millunchick J, Solomon MJ, Burns MA, “Selective Arraying of Complex Particle Patterns,” Lab on a Chip, 10(9), 1142-1147 (2010).
Solomon MJ, Zeitoun R, Ortiz D, Sung KE, Deng D, Shah A, Burns MA, Glotzer SC, Millunchick JM, “Toward Assembly of Non-close-packed Colloidal Structures from Anisotropic Pentamer Particles,” Macromolecular Rapid Communications, 31(2) 196-201 (2010).
S. J. Kim, F. Wang, M. A. Burns, K. Kurabayashi, “Temperature-programmed natural convection for micromixing and biochemical reaction in a single microfluidic chamber,” Analytical Chemistry, 81 (11), 4510-4516, 2009.
S. M. Langelier, D. S. Chang, R. I. Zeitoun, M. A. Burns, “Acoustically driven programmable liquid motion using resonance cavities,” Proceedings of the National Academy of Sciences of the United States of America, 106 (31), 12617-12622, 2009.
F. Wang, M. A. Burns, “Performance of nanoliter-sized droplet-based microfluidic PCR,” Biomedical Microdevices, 11 (5), 1071-1080, 2009..