McCauley is the William K. and Mary Anne Najjar Professor of Dentistry and professor in the Department of Pathology at the U-M Medical School. She earned her BS, DDS, MS and PhD (in veterinary pathobiology) from The Ohio State University. McCauley was a visiting scientist/professor at the Institut de Genetique et de Biologie Molecular et Cellulaire, the Ecole Normale Superieure de Lyon, and the Center for Experimental Therapeutics and Reperfusion Injury at Brigham and Women’s Hospital at the Harvard School of Medicine. McCauley is a diplomate of the American Board of Periodontology, a fellow with the American Association for the Advancement of Science, a former council member of the American Society for Bone and Mineral Research (ASBMR), former associate editor of the Journal of Bone and Mineral Research, a fellow in the American College of Dentists and the International College of Dentists. She also served on the National Institutes of Health, National Advisory Dental & Craniofacial Research Council.
For more than 20 years, McCauley has led an active research program in hormonal controls and cellular mechanisms of bone remodeling, parathyroid hormone anabolic actions in bone, and prostate cancer skeletal metastasis.
Hormonal controls of bone remodeling; Anabolic actions of parathyroid hormone (PTH), parathyroid hormone-related protein (PTHrP) and their dependence on the PTH-1 receptor and AP-1 transcription factors to evoke their anabolic actions; Impact and therapeutic potential of PTH in craniofacial osseous wound healing; The role of PTHrP and the bone marrow microenvironment in the pathophysiology associated with skeletal metastasis; Interactions of hematopoietic cells and PTH/PTHrP actions in the bone microenvironment
Park SI, Lee C, Sadler WD, Koh AJ, Soki FN, Cho SW, Daignault SD, McCauley LK. Parathyroid hormone-related protein supports prostate cancer growth through a CD11b+Gr1+ cell-mediated feedback loop. Cancer Research: 73: 6574-83, 2013, PMID: 24072746.
Cho SW, Soki FN, Koh AJ, Eber M, Entezami P, Park SI, van Rooijen N, McCauley LK. Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone. PNAS: 111: 1545-50, 2014. PMID: 24406853, PMCID: PMC3910564
McCauley LK, Dalli J, Koh AJ, Chiang N, Serhan CN. Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2. J Immunol 193:26-29, 2014. PMID: 24890726
Soki FN, Koh AJ, Jones JD, Kim YW, Dai J, Keller ET, Pienta KJ, Atabai K, Roca H, McCauley LK. Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis. J Biol Chem:289:24560-72, 2014. PMID 25006249
Khan AA, Hanley DA, Felsenberg D, McCauley LK, O’Ryan F, Reid IR, Ruggerio S, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Sheung AM, Morin SN, Masri B, Cooper C, Morgan S, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler D, Sandor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J. Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus. Journal of Bone and Mineral Research: 30:3-23, 2015, PMID:25414052 .
Weilbaecher KN, Guise TA, McCauley LK. Cancer to bone: a fatal attraction: Nature Reviews Cancer: 11:411-25. PMID: 21593787.