Ph.D. University of Maryland. Pharmaceutical Sciences. 2002.
B.Sc. Cairo University, Egypt. Pharmacy & Pharmaceutical Chemistry. 1994.
Professor ElSayed's research program at the Cellular Engineering & Nano-Therapeutics Laboratory focuses on the development of sophisticated drug delivery systems that enhance the therapeutic activity of the incorporated drug molecules while eliminating or minimizing their potential side effects by selectively targeting the diseased tissue with cellular and sub-cellular accuracy. To achieve this goal, his lab designs and synthesizes novel polymeric carriers that can effectively shuttle anticancer, antiviral, and nucleic acid drugs to the desired therapeutic targets. One example of Dr. El-Sayed's research projects involves the development of nano-sized polymer-anticancer drug conjugates that can selectively accumulate and release the loaded drug into hepatic cancer cells, which is a novel and promising approach for treatment of primary liver cancer. Another example involves the formulation of "smart" particles that can successfully shuttle large doses of nucleic acid drugs into breast cancer cells to "silence" the expression of faulty genes and trigger cancer cell death.
Scott H. Medina, Venkatesh Tekumalla, Maxim Chevliakov, Donna S. Shewach, William Ensminger, and Mohamed E.H. El-Sayed, "N-acetylgalactosamine-functionalized dendrimers as liver-targeted carriers", Biomaterials, 32:4118-4129, 2011.
Stephanie Grainger, Juliana Valencia Serma, Steffi Sunny, Yun Zhou, Cheri X. Deng, and Mohamed E.H. El-Sayed, "Pulsed ultrasound enhances nanoparticle penetration into breast cancer spheroids", Molecular Pharmaceutics, 7(6): 2006-2019, 2010.
Adam A. Dinerman, Joseph Cappello, Mohamed E.H. El-Sayed, Stephen W. Hoag, and Hamidreza Ghandehari, " Influence of solute charge and hydrophobicity on partitioning and diffusion in a genetically engineered silk-elastin like protein polymer hydrogel", Macromolecular Bioscience, 10:1235-1247, 2010.
Jallal El Hazzat and Mohamed E.H. El-Sayed, "Advances in targeted breast cancer therapy", Current Breast Cancer Reports, 2:146-151, 2010.
Yen-Ling Lin, Guohua Jiang, Lisa Birrell, and Mohamed E.H. El-Sayed, "Degradable, pH-sensitive, membrane-destabilizing, comb-like polymers for intracellular delivery of nucleic acids", Biomaterials, 31(27): 7150-7166, 2010.
Juyoung Park, Zhenzhen Fan, Ronald E. Kumon, Mohamed E.H. El-Sayed, and Cheri X. Deng, "Modulation of intracellular calcium concentration in brain microvascular endothelial cells in vitro by acoustic cavitation", Ultrasound in Medicine and Biology, 36(7): 1176-1187, 2010.