Medical School or Training: University of Illinois College of Medicine, 1981
Residency: Children's Memorial Hospital, Northwestern University Medical School, Chicago, IL, 1984
Fellowship: Pediatric Pulmonary & Intensive Care, Children's Hospital Boston, Harvard Medical School, Boston, MA 1988
The focus of Dr. Hershenson's research is chronic airways disease in children, including asthma, cystic fibrosis and bronchopulmonary dysplasia. His work combines cell culture and animal models of these diseases, and lately he has incorporated human studies into his research program. He also has experience in the delineation of biochemical signal transduction pathways regulating lung cell proliferation, differentiation and cytokine secretion. His main focus right now is the role of rhinovirus infections in the exacerbation and development of airways diseases. Specific research projects include:
1. Viral-induced asthma exacerbations.
2. Role of early-life viral infections in the development of asthma
3. Role of periostin and other matricellular proteins in the pathogenesis of asthma.
Chung Y, Hong J-Y, Lei J, Chen Q, Bentley JK, Hershenson MB. Rhinovirus infection of mice with allergic airways disease induces IL-13 production from CD11b-positive, M2-polarized exudative macrophages. Am J Respir Cell Mol Biol 2015; 52:205-16
Bentley JK, Chen V, Lei J, Hong J-Y, Popova AP, Moore BM, Hershenson MB. Periostin is required for house dust mite-induced airways inflammation and hyperresponsiveness. J Allergy Clin Immunol 2014; 134:1433-42.
Hong JY, Chung Y, Steenrod J, Comstock AT, Goldsmith AM, Bentley JK, Sajjan US, Hershenson MB. Macrophage activation state determines the response to subsequent rhinovirus infection in a mouse model of allergic asthma. Respir Res 15:63, 2014.
Popova AP, Bentley JK, Richardson MN, Linn MJ, Lei J, Chen Q, Goldsmith AM, Pryhuber GS, Hershenson MB. Reduced platelet-derived growth factor receptor expression is a primary feature of human bronchopulmonary dysplasia. Am J Physiol: Lung Cell Mol Physiol 307:L231-9, 2014.
Hong JY, Bentley JK, Chung Y, Lei J, Steenrod JM, Chen Q, Sajjan US, Hershenson MB. Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness via IL-25 and type 2 innate lymphoid cells. J Allergy Clin Immunol (Editor’s Choice) 134:429-39, 2014.
Ramirez IA, Caverly LL, Kalikin LM, Goldsmith AM, Lewis TC, Burke DT, LiPuma JJ, Sajjan US, Hershenson MB. Differential responses to rhinovirus and influenza infection in patients with cystic fibrosis exacerbations. Ann Am Thorac Soc 11:554-61, 2014.
Saba TG, Chung Y, Hong J-Y, Sajjan US, Bentley JK, Hershenson MB. Rhinovirus-induced macrophage cytokine expression does not require viral endocytosis or replication. Am J Respir Cell Mol Biol 50:974-84, 2014.
Bentley JK, Sajjan US, Dzaman MB, Jarjour NN, Lee W-M, Gern JE, Hershenson MB. Rhinovirus colocalizes with CD68- and CD11b-positive macrophages after experimental infection in humans. J Allergy Clin Immunol 132:758-761, 2013.
Schneider D, Hong JY, Bowman ER, Chung Y, Nagarkar DR. McHenry CL, Linn MJ, Goldsmith AM, Bentley JK, Lewis TC, Hershenson MB. Macrophage/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease. Am J Physiol: Lung Cell Mol Physiol. 304:L162-9, 2013
Lewis TC, Henderson TA, Ramirez IA, McHenry CL, Goldsmith AM, Ren X, Mentz G, Mukherjee B, Robins TG, Joiner T, Mohammad L, Roe E, Carpenter A, Burns MA, Burke DT, Hershenson MB. Nasal cytokine responses to natural colds in asthmatic children. Clin Exp Allergy (Editor’s Choice) 42:1734-44, 2012.
Popova AP, Bentley JK, Linn MJ, Lei J, Wong EJ, Goldsmith AM, Pryhuber GS, Hershenson MB. Glycogen synthase kinase-3β/β-catenin signaling regulates neonatal lung mesenchymal stromal cell myofibroblastic differentiation. Am J Physiol: Lung Cell Mol Physiol. 303:L439-48, 2012.
Schneider D, Hong JY, Popova AP, Bowman ER, Linn MJ, McLean AM, Zhao Y, Sonstein J, Bentley JK, Weinberg JB, Lukacs NW, Curtis JL, Sajjan U, Hershenson MB. Neonatal RV infection induces mucus cell metaplasia and airways hyperresponsiveness. J Immunol, 2012; 188:2894-904.
Bozyk PD, Popova AP, Bentley JK, Anyanwu AC, Linn MD, Pryhuber GS, Moore BB, Hershenson MB. Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplification. PLoS One 2012;7:e31336
Wang Q, Miller DJ, Bowman ER, Nagarkar DR, Schneider D, Zhao Y, Linn MJ, Goldsmith AM, Bentley JK, Sajjan US, Hershenson MB. MDA5 and TLR3 signaling initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness. PLoS Pathog. 7:e1002070, 2011.
Bozyk PD, Popova AP, Bentley JK, Goldsmith AM, Spees JL, Weiss DJ, Hershenson MB. Mesenchymal stem cells from neonatal tracheal aspirates demonstrate a pattern of gene expression consistent with a lung origin. Stem Cells Dev 20:1995-2007, 2011.
Bentley JK, Popova AP, Bozyk PD, Linn MJ, Baek AE, Lei J, Goldsmith AM, Hershenson MB. Ovalbumin sensitization and challenge increases the number of lung cells possessing a mesenchymal stem cell phenotype. Respir Res 11:127, 2010
Nagarkar DR, Bowman ER, Schneider D, Wang Q, Shim J, Zhao Y, Linn MJ, McHenry CL, Bentley JK, Tsai WC, Lukacs NW and Hershenson MB. Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages. J Immunol 185:2525-35, 2010.
Popova AP, Bozyk PD, Bentley JK, Linn MJ, Goldsmith AM, Schumacker RE, Filbrun AG, Weiner GM and Hershenson MB. Isolation of mesenchymal stem cells from tracheal aspirates of premature infants with respiratory distress predicts bronchopulmonary dysplasia. Pediatrics 126:e1127-33, 2010.