Dr. Aslam's research focuses on the chemoprevention of colon cancer, mainly interrogating the role of calcium, other cationic trace elements and the extracellular calcium sensing receptor in colon epithelial cell growth control. Extensive in vitro work has been completed in monolayer and 3D culture models, to determine the effects of calcium and trace minerals from calcium rich-marine algae with the notion that these trace minerals (mainly lanthanide family-rare earth elements) in conjunction with calcium are effective to reduce proliferation and induce differentiation in colon cells. Long-term interventional dietary studies in mice have demonstrated the efficacy of calcium in conjunction with additional trace minerals in suppressing colonic polyps in the context of high-fat Western-style diet. These studies established that better chemoprevention can be achieved with a combination of trace minerals as compared to calcium alone. These studies also confirmed that these interventions can alter the host gut microbial communities and microbially derived metabolites (bile acids and short chain fatty acids). Later, Dr. Aslam conducted a phase I clinical trial (using an FDA-granted IND) to test the same hypothesis in human subjects at risk for colon cancer. His ultimate goal is to find a better chemopreventive agent for the prevention of colon cancer. Recently, Dr. Aslam and Dr. Fan started a collaboration to test a laser emission based microscopy (developed by Dr. Fan) employing pre-neoplastic tissue from mouse and human colon, to detect early-stage nuclear changes, an effort to improve the existing detection modalities.