2002 BS, Bioengineering, University of California, Berkeley
2008 PhD, Bioengineering, Rice University
2012 Postdoc, Materials Science and Biological Engineering, MIT
Hydrogel matrix for HIV Vaccine
Mucosal tissues are the major site of pathogen entry and initial infection for many dangers microbes, such as HIV. However, little is known about vaccination strategies to induce effective mucosal immune responses. In this project, we are aiming to develop a synthetic scaffold system as a platform for HIV vaccine.
We apply the principles of tissue engineering and drug delivery to construct hydrogel scaffold materials that can manipulate local tissue microenvironments and induce cellular and humoral immunity in mucosal tissues against HIV.
Hydrogel matrix for HIV Vaccine
Nanoparticle vaccines for eradication of metastatic tumors
Our immune system has been developed to detect and eliminate foreign pathogens by generating local and systemic immune responses. If we can harness the potential of our own immune system and engineer cancer immunotherapy that can sense and eradicate tumors, this new therapeutic strategy will transform the field of cancer therapy.
We are developing nanoparticle vaccines that can induce anti-tumoral cytotoxic CD8+ T cell responses. Such cancer immunotherapy approach takes advantage of targeting capability of nanoparticles with controlled release of encapsulated cargo molecules to elicit potent T cell responses that can destroy target cancer cells not only in primary tumors but also in disseminated, metastatic tumors.
- Demuth PC, Moon JJ, Suh H, Hammond PT, and Irvine DJ, and Huang B. Layer-by-layer assembly of stabilized lipid nanocapsules on microneedles for enhanced transcutaneous vaccine delivery, ACS Nano, In press.
Moon JJ, Huang B, and Irvine DJ. Engineering nano- and micro-particles to tune immunity, DOI 10.1002/adma.201200446, 2012, Advanced Materials.
- Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, and Irvine DJ. Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction, 109, 1080-5, 2012, PNAS. -– Featured by PNAS: Commentary, 109, 999-1000, 2012.
Moon JJ, Suh H, Polhemus ME, Ockenhouse CF, Yadava A, and Irvine DJ. Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agent for Plasmodium vivax malaria vaccine, 7, e31472, 2012, PLoS One.
- Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Chiu W, and Irvine DJ. Interbilayer-crosslinked multilamellar vesicles for potent humoral and cellular immune responses, 10, 243-251, 2011, Nature Materials – Featured by Nature Materials: News and Views, 10, 166-68, 2011, and Nature Biotech: Research Highlights, 29, 330, 2011.
Bershteyn A, Hanson MC, Crespo MP, Moon JJ, Li AV, Suh H, and Irvine DJ. Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine, In press, 2011, Journal of controlled release.
- Stephan MT, Moon JJ, Um SH, Bershteyn A, and Irvine DJ. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles, 16, 1035-41, 2010, Nature Medicine.
Moon JJ, Saik JE, Poche RA, Leslie-Barbick JE, Lee SH, Smith AA, Dickinson ME, and West JL. Biomimetic hydrogels with pro-angiogenic properties, 31, 3840-3847, 2010, Biomaterials.
- Hu Y, Atukorale PU, Lu JJ, Moon JJ, Um SH, Cho EC, Wang Y, Chen J, and Irvine DJ. Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles, 10, 756-765, 2009, Biomacromolecules.
Moon JJ, Hahn MS, Kim I, Nsiah BA, and West JL. Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis, 15, 579-585, 2009, Tissue engineering.
- Leslie-Barbick JE, Moon JJ, and West JL. Covalently-Immobilized Vascular Endothelial Growth Factor Promotes Endothelial Cell Tubulogenesis in Poly(ethylene glycol) Diacrylate Hydrogels, 20, 1763-1779, 2009, Journal of biomaterials science.
Moon JJ, and West JL. Vascularization of engineered tissues: approaches to promote angiogenesis in biomaterials, 8, 300-310, 2008, Current topics in medicinal chemistry.
- Lee SH*, Moon JJ*, and West JL. Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration, 29, 2962-2968, 2008, Biomaterials.
Gobin AM*, Moon JJ*, and West JL. EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells, 3, 351-358, 2008, International journal of nanomedicine.
- Moon JJ, Lee SH, and West JL. Synthetic biomimetic hydrogels incorporated with ephrin-A1 for therapeutic angiogenesis, 8, 42-49, 2007, Biomacromolecules.
Lee SH, Moon JJ, Miller JS, and West JL. Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration, 28, 3163-3170, 2007, Biomaterials.
- Hahn MS, Taite LJ, Moon JJ, Rowland MC, Ruffino KA, and West JL. Photolithographic patterning of polyethylene glycol hydrogels, 27, 2519-2524, 2006, Biomaterials.
Lee P, Lin R, Moon J, and Lee LP. Microfluidic alignment of collagen fibers for in vitro cell culture, 8, 35-41, 2006, Biomedical microdevices.
- DeLong SA, Moon JJ, and West JL. Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration, 26, 3227-3234, 2005, Biomaterials.
Lee SH, Miller JS, Moon JJ, and West JL. Proteolytically degradable hydrogels with a fluorogenic substrate for studies of cellular proteolytic activity and migration, 21, 1736-1741, 2005, Biotechnol Progr.
- Moon JJ, Matsumoto M, Patel S, Lee L, Guan JL, and Li S. Role of cell surface heparan sulfate proteoglycans in endothelial cell migration and mechanotransduction, 203, 166-176, 2005, J Cell Physiol. (selected as a cover)
Li S, Moon JJ, Miao H, Jin G, Chen BP, Yuan S, Hu Y, Usami S, and Chien S. Signal transduction in matrix contraction and the migration of vascular smooth muscle cells in three-dimensional matrix, 40, 378-388, 2003, J Vasc Res.