1990 BA; Neurobiology--University of California, Berkeley
1990-1992 Assistant Scientist; Shaman Pharmaceuticals, San Carlos, CA
1998 Ph.D.; Neuroscience--University of California at Los Angeles
1998-2003 Postdoc; Molecular Genetics-- University of California at Los Angeles
2003-present Faculty UM Medical School
My primary research interests encompass two areas in Neuroscience. The first area is centered on how voltage-gated ion channels modulate neuronal function and how this in turn, shapes complex behavior. To this end, my group makes and uses mice that have been genetically engineered to either lack specific genes, over-express specific gene products or produce gene products that have been functionally altered. Using a multidisciplinary approach that combines aspects of modern molecular biology, behavioral neuroscience and electrophysiology, the lab is currently investigating several different classes of ion channels including 1) L-type voltage-gated calcium channels 2 ) the voltage-gated sodium channel NaV1.6. / / The second research area, which is a relatively new interest for me (within the last 3 years), focuses on the neurobiological substrates that underlie mesial temporal lobe epilepsy (mTLE). In collaboration with Dr. Jack Parent in Neurology we are investigating the role that dysregulation of adult neurogenesis in the dentate gyrus of the hippocampus plays in the generation of the epileptic state in mTLE. It has previously been demonstrated by the Parent lab (as well as others) that there is an aberrant increase in neurogenesis in rodent models of mTLE and in hippocampal tissue recovered from mTLE patients. Currently, we are using rodent models in which granule cells can be fluorescently labeled at the time of birth to investigate how the relationship between date of birth and seizure proximity influences the morphology, intrinsic excitability and connectivity of newborn granule cells. Finally, in collaboration with the Parent Lab and Dr. Oren Sagher in Neurosurgery, we have been investigating the intrinsic excitability and connectivity of granule cells in the human hippocampus by making whole-cell recording from in vitro slices prepared from human hippocampal tissue recovered by surgical resection (recently reviewed by Parent & Murphy 2008).
For publications please visit https://scholar.google.com/citations?hl=en&user=T6TDZHAAAAAJ&view_op=list_works&sortby=pubdate