Ph.D. University of Washington.
M.S.D. Indiana University.
B.D.S. University of Bombay, India. Dentistry.
Head and neck cancer is an aggressive, treatment-resistant cancer with a high recurrence rate. Invasion is required for development and spread of head and neck cancer but there are no strategies that effectively target invasion. This knowledge gap is due to limited progress in identifying and understanding the underlying mechanisms that control invasion. Our laboratory combines cutting edge in vitro models, pre-clinical models, and clinical studies to understand invasion. We investigate the tumor-microenvironment interactions that promote growth, spread and treatment resistance in cancer.
Banerjee R, Russo N, Liu M, Basrur V, Bellile E, Palanisamy N, Scanlon CS, van Tubergen E, Inglehart RC, Metwally T, Mani R, Yocum A, Nyati M, Castilho R, Varambally S, Chinnaiyan AM, and D’SilvaNJ. TRIP13 routes DNA repair to error-prone non homologous end joining to promote chemoresistance in human head and neck cancer. Nature Communications, 2014; 5:4527. PMC4130352
Scanlon CS, Banerjee R, Inglehart RC, Liu M, Russo N, Hariharan A, van Tubergen EA, Corson SL, Asangani IA, Mistretta CM, Chinnaiyan AM, and D’SilvaNJ. Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Nature Communications, 2015; 6:6885. PMC4476386
Piao S, Inglehart RC, Scanlon CS, Russo N, Banerjee R, D’SilvaNJ. CDH11 inhibits proliferation and invasion in head and neck cancer. J Oral Pathol Med. 2017 46(2):89-97. PMID:2739710
Russo N, Bellile E, Murdoch-Kinch CA, Liu M, Eisbruch A, WolfGT, and D’Silva NJ. Cytokines in saliva increase in head and neck cancer patients after treatment. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Oct;122(4):483-490. PMID: 27554375; PMC5031552
De Medeiros M, Banerjee R, Liu M, Anovazzi G, *D’SilvaNJ, *Rossa C. HNSCC subverts PBMCs to secrete soluble products that promote tumor cell proliferation. Oncotarget, 2017 Jun 15;8(37):60860-60874. PMC5617390 *Co-corresponding author.