Dr. Noriaki Ono is originally from Tokyo, Japan and born in a family with a lineage of dentists and orthodontists. He graduated summa cum laude from Tokyo Medical and Dental University in 2003 and earned his DDS degree. He received his orthodontic certificate and PhD degree from Tokyo Medical and Dental University in 2007, and continued clinical fellowship in orthodontics for two years at the same institute. He became a diplomate of the Japanese Board of Orthodontics in 2008. Dr. Ono came to the United States in 2009 to participate in the Endocrine Unit of Massachusetts General Hospital to focus on more advanced research activities on bone biology. He spent three years as a research fellow and two years as an instructor under the mentorship of Dr. Henry Kronenberg, while teaching as a part-time clinical instructor in the orthodontics program of Harvard School of Dental Medicine. In 2014, Dr. Ono was recruited to the University of Michigan as an Assistant Professor in Orthodontics and Pediatric Dentistry.
Dr. Ono’s research focuses on the fundamental biology of stem and progenitor cells of the chondrocyte and osteoblast lineage, with a further scope on understanding pathophysiology of dental, craniofacial and skeletal deformities and diseases that affect millions of children and adults. His research has been supported by the National Institute of Health since 2012.
Mizuhashi K, Ono W, Matsushita Y, Sakagami N, Takahashi A, Saunders TL, Nagasawa T, Kronenberg HM, Ono N. Resting zone of the growth plate harbors a unique class of skeletal stem cells. Nature. 2018, In Press.
Sakagami N, Matsushita Y, Howle-Syklawer S, Kronenberg HM, Ono W, Ono N. Msx2 marks spatially-restricted populations of mesenchymal precursors. J Dental Research. 2018, 97(11):1260-1267. PMID: 29746183
Ono N, Ono W, Nagasawa T, Kronenberg HM. A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones. Nature Cell Biology. 2014, 16(12):1157-67. PMID: 25419849, PMCID: PMC4250334
Ono N, Ono W, Mizoguchi T, Nagasawa T, Frenette PS, Kronenberg HM. Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage. Developmental Cell. 2014, 29(3):330-9.PMID: 24823376, PMCID: PMC4083679