Li completed his undergraduate study in Biological Sciences at Tsinghua University, and then joined the University of Southern California to pursue his Ph.D. in Neuroscience in the laboratory of Dr. Henry Sucov. Following his graduate work, he joined Dr. Mark Krasnow’s laboratory at Stanford University to study neural control of breathing. There, he and his colleagues identified the neuropeptide circuit underlying a breathing variant — sighing.
Peng Li’s primary research interest is to understand molecular and neural basis of breathing, a fundamental body function maintaining homeostasis. The Li lab is integrating cutting-edge molecular genetics and neuroscience approaches to study how brain interprets and responds to sensory cues and internal states to control breathing, and how this process could go awry in pathological conditions, such as in sleep apnea and sudden infant death syndrome.
Li P, Yackle K. Current biology : CB. 2017; 27(3):R88-R89. The peptidergic control circuit for sighing.
Li P, Janczewski WA, Yackle K, Kam K, Pagliardini S, Krasnow MA, Feldman JL. Nature. 2016; 530(7590):293-297. NIHMSID: NIHMS765909 Dysregulated endocardial TGFÎ² signaling and mesenchymal transformation result in heart outflow tract septation failure.
Ma M, Li P, Shen H, Estrada KD, Xu J, Kumar SR, Sucov HM. Developmental biology. 2016; 409(1):272-276. NIHMSID: NIHMS750618 MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons.
Engelhard C, Sarsfield S, Merte J, Wang Q, Li P, Beppu H, Kolodkin AL, Sucov HM, Ginty DD. eLife. 2013; 2:e01160.Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis.
Li P, Pashmforoush M, Sucov HM. Developmental biology. 2012; 361(1):116-24. NIHMSID: NIHMS339072