M.D., 1978, Duke University School of Medicine
My research centers on the role of eicosanoid lipid mediators, specifically prostaglandins and leukotrienes, in lung inflammation, antimicrobial defense, and fibrosis. Using tools of molecular and cell biology, cells from diseased patients, as well as animal models of disease, we focus on how eicosanoids influence macrophage and fibroblast function – which requires understanding the synthesis of these molecules as well as their receptors and signaling programs. Our ultimate goal is to gain novel insights into lung homeostasis and disease pathogenesis, and to identify new strategies for therapeutic targeting. The laboratory consists of a highly interactive and collaborative group of M.D. and Ph.D. trainees from around the world.