Education: Ph.D. University of Paris, France. Cellular and Developmental Biology. 2000.
M.S. University of Paris, France. Biomedical Sciences.
D.D.S. University of Paris, France. Oral Biology.
Project 1: Stem Cells, Biomaterials (bioglass, extracellular matrix, PLLA, silver), and Tissue Regeneration (mineralized tissues, glands, epithelial tissues).
We look forward to collaborate with other scientists with interest in tissue regeneration field and more particular in a) dental tissue regeneration; b) salivary gland regeneration (or gland regeneration in general); c) epithelial tissue regeneration. We are using a combination of synthetic scaffolds and/or natural extra-cellular matrix scaffolds and several types of human stem cells we isolated. We have also developed new composite materials that in addition to regenerative properties have also anti-bacterial properties and showed increased bonding to the surrounded tissues.
Project 2: Clock Genes, Auto-immune Diseases (Diabetes type I and Sjogren syndrome), and Cancer (salivary glands cancer and pancreatic cancer).
We look forward to collaborate with other scientists with interest in the role of clock genes and circadian rhythms in the pathogenesis of auto-immune disease such as Diabetes type I and Sjrogren syndrome. We are also interested to understand the role of clock genes in inflammation and cancer formation using two different models of gland-related cancerigenesis: salivary glands tumors and pancreatic cancer. We have also developed unique clock genes mutant mice that will allow to further study their role in human diseases.
Athanassiou-Papaefthymiou M, Papagerakis S, and Papagerakis P. Isolation, Clonal Expansion and Genetic Profile of Human Adult Stem Cells from the Epithelial Cell Rests of Mallassez. Eur Cell Materials, in press.
Athanassiou-Papaefthymiou M, Wangsawihardja F, Pliakas M, Lapadatescu C, Ma H, Ma PX, Papagerakis S, and Papagerakis P. Integrin-α6+ve cells from the Human Epithelial Cell Rests of Malassez generate enamel and dentin in vivo. Front Craniof Biol, in press.
Tanne K, Papagerakis P, Papaccio P, Kitamura C, and Tanimoto K. Tissue Regeneration in Dentistry. Int J Dent, in press.
Chatzistavrou X, Silvana Papagerakis S, Ma PX, and Papagerakis P. Innovative Approaches to Regenerate Enamel and Dentin. Int J Dent, in press.
Zheng L, Seon Y, McHugh J, Papagerakis S, and Papagerakis P. Clock Genes Show Circadian Rhythms in Salivary Glands. J Dent Res, 91(8):783-8. Selected for the cover of JDR August issue.
Papagerakis P, Pannone G, Shabana AH, Depondt J, Santoro A, Ghirtis K, Berdal A, Papagerakis S. Aberrant beta-catenin and LEF1 expression may predict the clinical outcome for patients with oropharyngeal cancer. Int J Immunopathol Pharmacol, 25:135-146, 2012.
Athanassiou-Papaefthymiou M, Kim D, Harbron L, Papagerakis S, Schnell S, Harada H, and Papagerakis P. Molecular and circadian controls of ameloblasts. Eur J Oral Sci, 119 Suppl 1:35-40, 2011.
Zheng L, Papagerakis S, Schnell SD, Hoogerwerf WA, and Papagerakis P. Expression of clock proteins in developing tooth. Gene Expression Patterns, 11:202-206, 2011.
Mitsiadis T, and Papagerakis P. Regenerated teeth: the future of tooth replacement? Editorial, Regen Med, 6:135-139, 2011.
Simmer JP, Papagerakis P, Smith CE, Fisher DC, Rountrey AN, Zheng L, Hu JC. Regulation of dental enamel shape and hardness. J Dent Res, 89:1024-38, 2010.