Martin Philbert is Professor of Toxicolgy and Dean of the University of Michigan School of Public Health. He is the Chair of the US FDA Science Advisory Board (terminates December 31, 2012) and as the Chair of the US EPA Board of Scientific Counselors (terminated June, 2012). He was elected to the Intitute of Medicine of the National Academies of Science in October 2012. He has published in excess of 200 peer-reviewed manuscripts, abstracts and book chapters and was awarded the Society of Toxicology Achievement Award (2000) and Communications Award (2012).
Several lipophilic environmental aromatic nitro-chemicals produce specific neuropathic lesions in the auditory and vestibular complexes of the brainstem. While some of the more likely biochemical pathways have been characterized, the predictive capacity of biochemical assays has been, at the very least, poor. This project will use computational approaches at the atomistc and meso- (e.g., mitochondrial and vesicular transport) levels to build unsupervised and unbiased predictive computational models for environmental (and therapeutic) chemicals that act as anitmetaolites and perturb local energy metabolism in the brain.
We aim to combine high-resolution optical imaging techniques and biochemical toxicology with atomistic and meso-scale compuational models to validate the approach and to buid robust algorithms for the prediction of target and (in the case of therapeutic entities) off-target toxicity.
Freudiger CW, Pfannl R, Orringer DA, Saar BG, Ji M, Zeng Q, Ottoboni L, Ying W, Waeber C, Sims JR, De Jager PL, Sagher O, Philbert MA, Xu X, Kesari S, Xie XS, Young GS. Lab Invest. 2012 Nov;92(11):1661.
Nie G, Hah HJ, Kim G, Lee YE, Qin M, Ratani TS, Fotiadis P, Miller A, Kochi A, Gao D, Chen T, Orringer DA, Sagher O, Philbert MA, Kopelman R.
Small. 2012 Mar 26;8(6):884-91. doi: 10.1002/smll.201101607. Epub 2012 Jan 9.
Wang Y, Liu X, Schneider B, Zverina EA, Russ K, Wijeyesakere SJ, Fierke CA, Richardson RJ, Philbert MA.
Toxicol Sci. 2012 Feb;125(2):509-21. Epub 2011 Nov 21.
Polunas M, Halladay A, Tjalkens RB, Philbert MA, Lowndes H, Reuhl K.
Neurotoxicology. 2011 Oct;32(5):526-34. Epub 2011 Aug 19.
Miller JA, Runkle SA, Tjalkens RB, Philbert MA.
Toxicol Sci. 2011 Aug;122(2):502-11. Epub 2011 May 6.
Steiner SR, Philbert MA.
Neurotoxicology. 2011 Aug;32(4):362-73. Epub 2011 Mar 23.
Maynard AD, Warheit DB, Philbert MA.
Toxicol Sci. 2011 Mar;120 Suppl 1:S109-29. Epub 2010 Dec 22. Review.
Wenger Y, Schneider RJ 2nd, Reddy GR, Kopelman R, Jolliet O, Philbert MA.
Toxicol Appl Pharmacol. 2011 Mar 15;251(3):181-90. Epub 2010 Dec 4.
Hah HJ, Kim G, Lee YE, Orringer DA, Sagher O, Philbert MA, Kopelman R.
Macromol Biosci. 2011 Jan 10;11(1):90-9.
Orringer DA, Chen T, Huang DL, Philbert M, Kopelman R, Sagher O.
Acta Neurochir Suppl. 2011;109:259-63.
Orringer DA, Chen T, Huang DL, Armstead WM, Hoff BA, Koo YE, Keep RF, PhilbertMA, Kopelman R, Sagher O.
Neurosurgery. 2010 Apr;66(4):736-43.