Ph.D. University of Michigan. 2001.
M.S.E. University of Michigan. 1996.
B.S. University of California, Los Angeles. 1994.
Our laboratory conducts both fundamental and applied research in the broad areas of cell and tissue engineering. Our fundamental research focuses on the instructive role of the extracellular matrix in the determination of cell fate, particularly on the role of matrix compliance (i.e., stiffness) and matrix remodeling during neovascularization (angiogenesis). The applied research then seeks to leverage this fundamental knowledge to design instructive materials as synthetic ECMs for applications in regenerative medicine and as model systems in which to study disease. We use a multidisciplinary combination of approaches from biomaterials, mechanobiology, stem cell biology, cell/molecular biology, and engineering.
J.R. Bezenah, A.Y. Rioja, B. Juliar, N. Friend, andÂ A.J. Putnam. “Assessing the ability of human endothelial cells derived from induced pluripotent stem cells to form functional microvasculature in vivo.” Biotechnology and Bioengineering, 116(2):415-426 (2019).
Y.P. Kong, A.Y. Rioja, X. Xue, Y. Sun, J. Fu, andÂ A.J. Putnam. “A Systems Mechanobiology Model to Identify Biomaterials that Support Cardiac Reprogramming.” Biomaterials, 181:280-292 (2018).
B.A. Juliar, M.T. Keating, Y.P. Kong, E.L. Botvinick, and A.J. Putnam. “Sprouting angiogenesis induces significant mechanical heterogeneities and ECM stiffening across length scales in fibrin hydrogels.” Biomaterials, 162:99-108 (2018).
J.R. Bezenah, Y.P. Kong, and A.J. Putnam. “Evaluating the potential of endothelial cells derived from human induced pluripotent stem cells to form microvascular networks in 3D cultures.” Scientific Reports, 8(1): 2671 (2018).
A. Moncion, M. Lin, E.G. O’Neill, R.T. Franceschi, O.D. Kripfgans, A.J. Putnam, and M.L. Fabiilli. “Controlled release of basic fibroblast growth factor for angiogenesis using acoustically-responsive scaffolds.” Biomaterials, 140:26-36 (2017).