Richard Hume is an Arthur F. Thurnau Professor and the Academic Program Director of the Undergraduate Program in Neuroscience.
The major interests of Professor Hume’s lab are the molecular bases of synaptic transmission and synaptic development. The majority of his current work is focused on a system that mediates excitatory transmission in mammalian brain. The major goals of current research in this lab include: (1) To identify the molecular motifs of P2X receptors that account for ATP binding, channel gating, and modulation of channel function; (2) To test the importance of P2X receptors in synaptic development; and (3) To understand the role that P2X receptor mediated signaling plays in the mature brain.
Low SE, Amburgey K, Horstick E, Linsley J, Sprague SM, Cui WW, Zhou W, Hirata H, Saint-Amant L, Hume RI, and Kuwada JY (2011) TRPM7 is required within zebrafish sensory neurons for the activation of touch-evoked escape behaviors. Journal of Neuroscience 31:11633-11644 PMID:21832193
Mouslim, C, Aittaleb, M, Hume, RI and Akaaboune, M (2012) A role for the CaM Kinase II related anchoring protein (αkap) in maintaining the stability of nicotinic Acetylcholine Receptors. Journal of Neuroscience 32:5177-85 PMID: 22496563
Punthambaker S, Blum JA, Hume RI, (2012) High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism. J Biol Chem. 287: 22099-22111 PMID: 22556417
Dellal, SS and Hume RI (2012) Covalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP. PLoS ONE 7(10): e47147. doi:10.1371/journal.pone.0047147
Xiong X, Sun, K, Mishra, B, Hume, RI, Wu C and Collins, CA (2012) The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein. PLOS Biology (in press)