Education: D.M.Sc. Harvard University. 1990.
D.M.D. University of Pennsylvania. 1986.
B.S. Villanova University. 1983.
Research in the laboratory of Dr. Russell Taichman focuses on the role of osteoblasts in normal bone marrow function. The laboratory is currently trying to identify the osteoblast-derived factor(s) that support hematopoiesis. Identifying these mechanisms may someday ultimately reduce the morbidity/mortality associated with bone marrow transplants and will likely lead to the identification of novel methods to improve bone engraftment for regenerative therapies. Recent NIDCR grants have allowed the group to dissect the molecular events that mediate cell-to-cell adhesion between osteoblasts and hematopoietic stem cells. Part of the receptor complex that has been uncovered is novel and may be involved in how stem cells return to the marrow during bone marrow transplantation. In a second related project, the group is studying the mechanisms used by tumor cells to metastasize to the bone marrow. It has been found that part of the mechanism relates to products secreted by osteoblasts in the bone marrow that interact with receptors on tumor cells. Currently the focus is on the receptor CXCR4 (an HIV co-receptor). This receptor binds stromal derived factor-1 (SDF-1) which we believe directs the chemotaxis of prostate cancers towards the marrow. In fact, the group has recently demonstrated that blocking CXCR4 resulted in fewer tumors in animals. Recently funded projects include examinations of genetic variability in these genes that regulate tumor progression and metastasis.
Y Jung, Y Shiozawa, J Wang, N McGregor, J Dai, SI Park, AM Havens, J Joseph, JK Kim, L Patel, P Carmeliet, S Daignault, ET Keller, LK McCauley, KJ. Pienta & RS Taichman. Prevalence of Prostate Cancer Metastases Following Intravenous Inoculation Provides Clues into the Molecular Basis of Dormancy in the Bone Marrow Microenvironment. Neoplasia. 2012 May;14(5):429-39. PMID: 22745589
A Mishra, J Wang, Y Shiozawa, S McGee, J Kim, Y Jung, J Joseph, A Havens, KJ Pienta, RS. Taichman. Hypoxia Induced Axl Stability Contributes to Metastasis in Prostate Cancer Cells Mol Cancer Res. 2012 Jun;10(6):703-12. Epub 2012 Apr 19. PMID:2251634
Y Shiozawa, EA Pedersen, AM Havens, Y Jung, AM Ziegler, M J Pienta, J Song, J Wang, RD Loberg, PH. Krebsbach, KJ Pienta, RS Taichman. Metastases target the hematopoietic stem cell niche to establish footholds in bone. J. Clinical Investigation, 2011:121(4) 1298-1312. PMID: 21436587. PMC3069764
Y Jung, Y Shiozawa, J Wang, LR Patel, AM. Havens, J Song, PH. Krebsbach, GD Roodman RS Taichman. Annexin 2 is a regulator of SDF-1/CXCL12 function in the hematopoietic stem cell endosteal niche. Exp Hematol. 2011 Feb;39(2):151-166.e1. Epub 2010 Nov 22. PMC3026087.
Y Shiozawa, EA Pedersen, AM Ziegler, AM Havens, Y Jung, J Wang, S Zalucha, RD Loberg, KJ Pienta, RS Taichman. GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. Neoplasia (2010) 12, 116–127.