Dr. Rui is a Professor of Molecular & Integrative Physiology at the University if Michigan School of Medicine. He received his Ph.D. from the University of Michigan.
The Rui laboratory studies cell signaling, metabolism, and metabolic diseases, focusing on obesity, diabetes, and liver diseases. We analyze insulin and leptin signaling in adipocytes, hepatocytes, and hypothalamic neurons to elucidate the molecular basis of their metabolic action and the mechanism of leptin and insulin resistance in the context of overnutrition and obesity. We examine genomic responses to metabolic signals and transcriptional regulation of glucose and lipid metabolism. We generate and metabolically phenotype cell type-specific knockout mouse models of obesity, diabetes, and liver diseases (e.g. SH2B1, Slug, Snail1, TRAF2, TRAF3, NIK), and we identify their underlying physiological mechanisms. We investigate hypothalamic neural circuits and their control of appetite, energy expenditure, body weight, and glucose/lipid metabolism, using fluorescent immunohistological and electrophysiological techniques. We study the hepatic lipogenic program and fatty acid ë_ oxidation and their contributions to nonalcoholic fatty liver disease (NAFLD) in the setting of inflammation and obesity. We study liver injury, regeneration, fibrosis, and cirrhosis, using genetic models as well as partial bile duct ligation and hepatectomy models. We study the interplay between the brain, liver, and adipose tissue in order to comprehensively understand obesity, diabetes, and liver diseases both at molecular and cellular levels and in animals.
Liang Sheng, Yingjiang Zhou, Zheng Chen, Decheng Ren, Kae Won Cho, Lin Jiang, Yoshiteru Sasaki, and Liangyou Rui. NF-•ÇB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nature Medicine. 18 (6):943-949, 2012
Zheng Chen, Liang Sheng, Robert Brink, and Liangyou Rui. Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses. Diabetes. 61(3):566-573, 2012
Hong Shen, Mengle Shao, Kae Won Cho, Suqing Wang, Zheng Chen, Liang Sheng, Ting Wang, Yong Liu, and Liangyou Rui. Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes and •¢ cells. American Journal of Physiology-Endocrinology and Metabolism. 302(8):E932-940, 2012.
Liang Sheng, Kae Won Cho, Yingjiang Zhou, Hong Shen, and Liangyou Rui. Lipocalin 13 protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid •¢ oxidation. Journal of Biological Chemistry. 286:38128-38135; 2011.
Kae Won Cho, Yingjiang Zhou, Liang Sheng, and Liangyou Rui. Lipocalin-13 regulates glucose metabolism through both insulin-dependent and -independent mechanisms. Molecular and Cellular Biology. 31(3):450-457; 2011