1987 – 1991 Wuhan University, P.R. of China, B.S. (Biochemistry)
1991 – 1994 Wuhan University, P.R. of China, M.S. (Biochemistry)
1995 – 2000 Johns Hopkins University, Ph.D. (Biological Chemistry)
2001- 2005, California Institute of Technology
Shawn Xu studies the genetic model organism C. elegans to understand fundamental processes in neuroscience, such as how the nervous system perceives sensory inputs, how neural circuits process information to generate behavior, and how genes regulate those processes. He takes a multidisciplinary approach, combining molecular genetics, cell biology, behavioral analysis, functional imaging and electrophysiology.
Wescott, S. A., M. Rauthan, et al. (2012). "When a TRP goes bad: Transient receptor potential channels in addiction." Life Sci.
Singaravelu, G., I. Chatterjee, et al. (2012). "The sperm surface localization of the TRP-3/SPE-41 Ca2+ -permeable channel depends on SPE-38 function in Caenorhabditis elegans." Dev Biol 365(2): 376-383.
Zheng, M., P. Cao, et al. (2012). "Calcium imaging of multiple neurons in freely behaving C. elegans." J Neurosci Methods 206(1): 78-82.
Park, E. C., P. Ghose, et al. (2012). "Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism." EMBO J 31(6): 1379-1393.
Zhang, D., N. R. Isack, et al. (2012). "RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway." J Cell Biol 196(1): 85-101.
Piggott, B. J., J. Liu, et al. (2011). "The neural circuits and synaptic mechanisms underlying motor initiation in C. elegans." Cell 147(4): 922-933.
Xiao, R. and X. Z. Xu (2010). "Mechanosensitive channels: in touch with Piezo." Curr Biol 20(21): R936-938.
Wang, G. J., L. Kang, et al. (2010). "GRLD-1 regulates cell-wide abundance of glutamate receptor through post-transcriptional regulation." Nat Neurosci 13(12): 1489-1495.
Kang, L., J. Gao, et al. (2010). "C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel." Neuron 67(3): 381-391.
Liu, J., A. Ward, et al. (2010). "C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog." Nat Neurosci 13(6): 715-722.