M.D., 1982, Jiangxi Medical College, Nanchang, P.R. China
Ph.D., 1989, The University of Iowa
The Sun laboratory is focused on understanding the molecular mechanisms involved in regulation of apoptosis, angiogenesis, and radioresistance by SCF E3 ubiquitin ligases and p53 signal pathways with the ultimate aim of identifying and validating targets for mechanism-driven, anti-cancer drug discovery.
He, H., and Sun, Y.: Ribosomal protein S27L is a direct p53 target that regulates apoptosis. Oncogene, 26: 2707-2716, 2007.
Gu, Q, Tan, M., and Sun, Y.: SAG/ROC2/Rbx2 is a novel AP-1 target that promotes c-Jun degradation and inhibits TPA induced neoplastic transformation. Cancer Res. 67: 3616-3625, 2007.
Gu, Q., Bowden, G.T., Normolle, D., Sun, Y.: SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkB-α/NF-kB. J. Cell Biol. 178:1009-1023, 2007. PMCID2064624.
Tan, M., Gu, Q., He, H., Pamarthy, D., Gemenza, G.L., and Sun, Y.: SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation. Oncogene, 27: 1404-1411, 2008.
Zheng, M., Morgan-Lappe, S., Yang, J., Bockbrader, K. M., Pamarthy, D., Thomas, D., Fesik, S., and Sun, Y.: Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by siRNA silencing of tumor necrosis factor receptor-associated factor 2. Cancer Res. 68:7570-7578, 2008. PMCID2597026.