Professor of Molecular and Integrative Physiology
Professor of Biomedical Engineering, College of Engineering
Ph.D. Physiology. 1981.
M.A. Auditory Science. 1975.
Over the past decade, my lab has been studying the contributions of multisensory systems to auditory processing. In particular, we discovered that “touch-sensitive” neurons in the brain, that receive input from the face and head, send neural projections to the auditory system. These projections terminate in the first stop in the brain, the cochlear nucleus, which receives input directly from the cochlea. Our work has shown that these “somatosensory” neurons can alter the cochlear nucleus response to sound. Most remarkably, after deafness, there is a strong enhancement in somatosensory influences on the cochlear nucleus, as if in compensation for the loss of input from the cochlea. An undesirable side effect of these somatosensory inputs, which are excitatory, is the development of tinnitus (ringing in the ear). Our most recent work demonstrates that in animals with tinnitus (tested behaviorally), the major change in the cochlear nucleus was an increase in excitation from the somatosensory system (see press release: http://www.uofmhealth.org/news/tinnitus-kresge-0201). Work extending these findings is now focused on synaptic plasticity as an underlying mechanism to explain the long-term nature of these changes. Ongoing work is laying the groundwork for treatments that include specific, patterned stimulation that may “reverse” the increased excitation that contributes to tinnitus. An alternative approach, in collaboration with Dr. Raphael, is to replace the lost auditory nerve input to the brain that is the trigger for the somatosensory compensation. We are also examining brain patterns in human patients with tinnitus with the goal of applying our animal research findings to alleviate tinnitus in humans.
Dehmel, S, Pradhan, S, Koehler, SC, Bledsoe S, and Shore, SE. ""Noise over-exposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus - possible basis for tinnitus-related hyperactivity?"" Journal of Neuroscience 32: 5, 1660-71, 2012 (Press Release: http://www.uofmhealth.org/news/tinnitus-kresge-0201).
Koehler, Pradhan, S S, Manis P, and Shore SE. Somatosensory inputs modify auditory spike timing in dorsal cochlear nucleus principal cells. European Journal of Neuroscience, 33:3, 409-420, 2011.
Zeng, C, Shroff, H., Shore SE. Cuneate and Spinal Trigeminal Nucleus Projections to the Cochlear Nucleus are Differentially Associated with Vesicular Glutamate Transporter2. Neuroscience, 17: 142-51, 2011.
Merriam, Sister ME, Dehmel S, Srivannavit O, Shore SE, Wise KD. A Three-Dimensional 160-Site Microelectrode Array for Cochlear Nucleus Mapping. IEEE Trans Biomed Eng,58:2, 397-403, 2010.
Zeng C, Nannapaneni N, Zhou, J and Shore SE. Cochlear damage changes the distribution of vesicular glutamate transporters associated with auditory nerve or non-auditory inputs to the cochlear nucleus. Journal of Neuroscience, 29: 4210-7, 2009.