Sarah Veatch is a classically trained physicist who applies physical principles to better understand how lipids in membranes influence biological processes.
Lipids are structural components of cell membranes that play vital roles in biological function. We are interested in understanding how the physical properties of lipids, lipid mixtures, and lipid-protein interactions influence functions in cell plasma membranes. To accomplish this, we draw on experimental and theoretical foundations in soft matter physics, physical chemistry, molecular and cell biology.
Quantitative nanoscale analysis of IgE-FcεRI clustering and coupling to early signaling proteins, (Veatch SL, Chiang EN, Sengupta P, Holowka DA, Baird BA), J Phys Chem B. 116(23):6923-35. (2012).
Correlation Functions Quantify Super-Resolution Images and Estimate Apparent Clustering Due to Over-Counting, (Veatch, Sarah L.; Machta, Benjamin B.; Shelby, Sarah A.; et al.) PLoS ONE 7(2): e31457. doi:10.1371/journal.pone.0031457.
Minimal Model of Plasma Membrane Heterogeneity Requires Coupling Cortical Actin to Criticality, (Machta BB, Papanikolaou S, Sethna JP, Veatch SL), Biophys J. 100(7): 1668–1677 (2011).
Critical Fluctuations in Plasma Membrane Vesicles, (S. L. Veatch, P. Cicuta, P. Sengupta, A. Honerkamp-Smith, D. Holowka, B. Baird), ACS Chem. Bio. 3, 287-293 (2008).