Ph.D. Kyoto University. 2001.
M.D. Kyoto University. 1992.
His lab's research is focused on defining the role of proteolytic extracellular matrix (ECM) remodeling as the major initiator of mechanotransduction in the disease processes of obesity, diabetes, and cardiovascular diseases (CVD). Particularly, they are interested in the biological process of angiogenesis (new blood vessel formation) and adipogenesis (adipocyte differentiation). By combining the approach of gene targeting in mice, three-dimensional (3-D) collagen model, or organ-on-chip, they aim to identify the novel outside-in signals that serve as the therapeutic targets for the treatment of obesity, diabetes, and CVD.
Hikage F, Atkins S, Kahana A, Smith TJ, Chun TH. HIF2A-LOX pathway promotes fibrotic tissue remodeling in thyroid-associated orbitopathy. Endocrinology. 2018 Nov 1;PubMed PMID: 30388216.
Buras ED, Converso-Baran K, Davis CS, Akama T, Hikage F, et al. Fibro-Adipogenic Remodeling of the Diaphragm in Obesity-Associated Respiratory Dysfunction. Diabetes. 2018 Oct 25;PubMed PMID: 30361289.
Akama T, Chun TH. Transcription factor 21 (TCF21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells. J Biol Chem. 2018 Apr 27;293(17):6603-6610. PubMed PMID: 29540474; PubMed Central PMCID: PMC5925812.
Barnes RH 2nd, Akama T, Öhman MK, Woo MS, Bahr J, et al. Membrane-Tethered Metalloproteinase Expressed by Vascular Smooth Muscle Cells Limits the Progression of Proliferative Atherosclerotic Lesions. J Am Heart Assoc. 2017 Jul 22;6(7)PubMed PMID: 28735290; PubMed Central PMCID: PMC5586255.
Akama T, Leung BM, Labuz J, Takayama S, Chun TH. Designing 3-D Adipospheres for Quantitative Metabolic Study. Methods Mol Biol. 2017;1566:177-183. PubMed PMID: 28244051; NIHMSID: NIHMS857477; PubMed Central PMCID: PMC5433799.
Lin, Chun TH, Kang L. Adipose extracellular matrix remodelling in obesity and insulin resistance. Biochem Pharmacol. 2016 Nov 1;119:8-16. PubMed PMID: 27179976; NIHMSID: NIHMS795618; PubMed Central PMCID: PMC5061598.