Ravitz Professor of Ophthalmology / Professor of Pathology
Dr. Elner is a double-boarded physician in ophthalmology and pathology. He performs research in all aspects of ophthalmic pathology including surgical pathology series, immunohistochemical studies, and most recently epigenetic study of inflammatory and neoplastic diseases. He has also performed study in the genetic aspect of predisposition to ophthalmic disease. During the last decade, Dr. Elner has done extensive research in ophthalmic imaging developing novel imaging of a fluorescent biomarker for metabolic dysfunction of the retina and quantitative assessment of novel and established fundus fluorescence images. Moreover, he has employed imaging as a translational tool capable of detecting preapoptotic and apoptotic responses in cells, animal tissues, and humans, in vitro, ex vivo, and in vivo using a novel non-invasive technique. Dr. Elner has investigated retinal pigment epithelial inflammatory and apoptotic responses and their dependence on cell-cell contact and receptors mediating the contact as well as on ambient cytokines and other agents. This work has been the object of 20 years of NIH-supported research.
Field MG et al. Noninvasive Imaging of Mitochondrial Dysfunction in Dry Age-Related Macular Degeneration. Opthalmic Surg Lasers Imaging 2012 (epub ahead of print)
Bien et al. Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2011;52:8646-56.
Field et al. Retinal flavoprotein fluorescence correlates with mitochondrial stress, apoptosis, and chemokine expression. Exp Eye Res 2011:93:548-55.
Yang et al. Activation of P2X receptors induces apoptosis in human retinal pigment epithelium. Invest Ophthalmol Vis Sci 2011 52:1522-30.
Yang et al. MCP-1-activated monocytes induce apoptosis in human retinal pigment epithelium. Invest Ophthalmol Vis Sci 2011;52:6026-34