Wanlu is an Assistant Research Scientist in the Department of Molecular, Cellular, and Developmental Biology at the University of Michigan.
Brain metastases are the most devastating complications of cancer, occurring in one-third of advanced cancer patients. The most common sources of brain metastases are lung cancer, breast cancer, and melanoma. Metastatic cancer cells extravasate from the blood vessel, colonize, outgrow and invade within the brain. Communication between invading cancer cells and brain microenvironment is an essential event during brain metastases, however little is known about the regulation of such process. My research interests focus on, 1) specific cancer cell vulnerability; 2) interaction between metastatic cancer cells and brain residual cells. We are using various in vivo mouse models (patient-derived brain tumor xenograft, brain metastases models, etc.) and a combination of in vivo BLI imaging, mouse genetics, FACS, histochemistry, primary cell culture, and molecular/protein analysis to study the specific cancer cell vulnerability and unique interaction between metastatic cancer cells and brain residual cells. We are hoping to elucidate the underlying mechanisms with the aim of identifying new targets for future therapeutics.
Reinshagen C, Bhere D, Choi SH, Hutten S, Nesterenko I, Wakimoto H, Le Roux E, Rizvi A, Du W, Minicucci C, Shah K.
Sci Transl Med. 2018 Jul 11;10(449). pii: eaao3240. doi: 10.1126/scitranslmed.aao3240.
Du W, Seah I, Bougazzoul O, Choi G, Meeth K, Bosenberg MW, Wakimoto H, Fisher D, Shah K.
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6157-E6165. doi: 10.1073/pnas.1700363114. Epub 2017 Jul 14.
Bagci-Onder T*, Du W*, Figueiredo JL, Martinez-Quintanilla J, Shah K.
Brain. 2015 Jun;138(Pt 6):1710-21. doi: 10.1093/brain/awv094. Epub 2015 Apr 23.
Du W, Uslar L, Sevala S, Shah K.
PLoS One. 2014 Apr 18;9(4):e95490. doi: 10.1371/journal.pone.0095490. eCollection 2014.
Li H*, Huang J*, Du W*, Jia C, Yao H, Wang Y.
J Neurochem. 2012 Dec;123(6):1010-8. doi: 10.1111/jnc.12045. Epub 2012 Nov 1.
Huang J, Du W, Yao H, Wang Y.
In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 10.
Du W*, Huang J*, Yao H, Zhou K, Duan B, Wang Y.
J Clin Invest. 2010 Oct;120(10):3480-92. doi: 10.1172/JCI43165. Epub 2010 Sep 1.
Tai Y, Feng S, Du W, Wang Y.
Pflugers Arch. 2009 Jun;458(2):283-9. doi: 10.1007/s00424-008-0618-y. Epub 2008 Nov 21. Review.
Tai Y, Feng S, Ge R, Du W, Zhang X, He Z, Wang Y.
J Cell Sci. 2008 Jul 15;121(Pt 14):2301-7. doi: 10.1242/jcs.026906. Epub 2008 Jun 17.
Zhou J*, Du W*, Zhou K, Tai Y, Yao H, Jia Y, Ding Y, Wang Y.
Nat Neurosci. 2008 Jul;11(7):741-3. doi: 10.1038/nn.2127. Epub 2008 May 30.
* Authors contributed equally.