Dr. Wu joined the Department of Molecular & Integrative Physiology in 2013. She is currently a research assistant professor of Life Sciences Institute (LSI), a member of the Cellular & Molecular Biology Program (CMB), Program in Biomedical Sciences (PIBS) and Center for Organogenesis. She received her Bachelor of Science in Biology from University of Science and Technology of China and then her Ph.D. in Biological Chemistry from the University of Michigan, respectively. After her Ph.D, Jun subsequently worked with Bruce Spiegelman at Dana-Farber Cancer Institute and Harvard Medical School as a postdoctoral fellow and instructor.
Professor Wu's work focuses on a recently identified form of fat cells, so-called “beige cells.” Genetic manipulations that create more of these fat cells in mice have strong anti-obesity and anti-diabetic effects.
van der Lans AA, Hoeks J, Brans B, Vijgen GH, Visser MG, Vosselman MJ, Hansen J, Jorgensen JA, Wu J, Mottaghy F, Schrauwen P and van Marken Lichtenbelt WD. (2013) Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest. 123(8):3395-403. PMID: 23867626.
Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP and Spiegelman BM. Fat cells directly sense temperature to activate thermogenesis. (2013). Proc Natl Acad Sci U S A. 110(30): 12480-5. PMID: 23818608.
Rajakumari S*, Wu J*, Ishibashi J, Hee-Woong L, Giang AH, Won KJ, Reed RR and Seale P. (2013) EBF2 determines and maintains brown adipocyte identity. Cell Metab. 17(4):562-74. PMID: 23499423. *These authors contributed equally to the work.
Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar, MJ, Boström P, Mepani R, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver, P, Griffin PR, Clapham D and Spiegelman BM. (2012) TRPV4 is a regulator of adipose oxidative metabolism, inflammation and energy homeostasis. Cell. 151(1):96-110. PMID: 23021218.
Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P and Spiegelman BM. (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 150(2):366-76. PMID: 22796012.