B.S. in Pharmacy and M.S. in Pharmaceutical Chemistry from University Ss. Cyril and Methodius, Skopje, Republic of Macedonia;
Ph.D. in Pharmaceutical Chemistry from her alma mater University with Professors Dorevski and Solmajer from National Institute of Chemistry in Ljubljana, Slovenia;
Postdoctoral training in drug discovery with Professor Shaomeng Wang at the University of Michigan
Chemical genomics: discovery and application of active chemical compounds for the interrogation of biological systems and improvement of human health; understanding the protein-protein interactions (PPIs) involved in controlling the programmed cell death and regulating epigenetic mechanisms; developing small molecule inhibitors as potential cancer therapeutics by using interdisciplinary approach combining biophysical and biochemical methods, structural biology, medicinal chemistry and functional biology.
Complete List of Published Work in MyBibliography
Shen C, Jo SY, Liao C, Hess JL, Nikolovska-Coleska Z. Targeting recruitment of Disruptor Of Telomeric silencing 1-Like (DOT1L): Characterizing the interactions between DOT1L and Mixed Lineage Leukemia (MLL) fusion proteins. J Biol Chem. 2013, 288(42):30585-96.
Abulwerdi FA, Liao C, Mady A, Gavin J, Shen C, Cierpicki T, Stuckey JA, Showalter HD, Nikolovska-Coleska Z. 3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR and Biological Evaluation J Med Chem. 2014, 57(10):4111-33 PMCID: PMC4033665
Abulwerdi F, Liao C, Liu M, Azmi AS, Aboukameela A, Mady AS, Gulappa T, Cierpicki T, Owens S, Zhang T, Sun D, Stuckey JA, Mohammad RM, Nikolovska-Coleska Z. A novel small-molecule inhibitor of Mcl-1 Blocks pancreatic cancer growth in vitro and in vivo. (Highlighted in Molecular Cancer Therapeutics Press Release, March 2014) Mol Cancer Ther. 13(3): 565-75, 2014. PMCID: PMC417457
Wei D, Zhang Q, Schreiber J, Parsels LA, Abulwerdi FA, Kausar T, Lawrence TS, Sun Y, Nikolovska-Coleska Z and Morgan MA. Targeting Mcl-1 for radiosensitization of pancreatic cancers. Translational Oncology 8(1): 47-54, 2015
Gibbons GS, Owens SR, Fearon ER, Nikolovska-Coleska Z. Regulation of Wnt Signaling Target Gene Expression by the Histone Methyltransferase DOT1L. (Highlighted in ACS Chem. Biol. Press Release, January 2015) ACS Chem. Biol. 10, 109-114, 2015
Nikolovska-Coleska Z.: Studying Protein-Protein Interactions using Surface Plasmon Resonance. Methods in Molecular Biology Protein-Protein Interactions: Methods and Applications, Editors: Cheryl Meyerkord and Haian Fu Humana Press, 2015. Second, 109-138